thalassemia is an autosomal recessive disorder associated with defective synthesis of the α- or β-chain of hemoglobin. for β-thalassemia major patients, therapeutic options are either monthly red cell transfusions and chelation therapy or allogeneic stem cell transplant. stem cell transplant is the only curative approach and success is inversely correlated with the degree of iron overload and h...

trying to use embryonic stem cells about 20 years ago, working with animals,  especially rats began. during these years , many experiments in mouse embryonic stem cells to transform into a variety of cells and transplanting them were led to remarkable success . in the next issue of human stem cells were considered successful until finally in 1998 the first report was published in the proliferat...

introduction: sharply progression and development in different aspect of technology and science in the field of medicine and sanitation bring many challenges in biological moral and social aspects of the life. meanwhile statistical problems of this subjects will be rised. study and researches on embryonic stem cells are one of this specimens. religions and different ideological views in vast hu...

introduction: gold standard for alveolar cleft bone grafting is autogenous bone. advantage of adding the growth factors to the bone is established, so adding prf to the autogenous bone may have beneficial effects. methods:  platelet-rich plasma admixed with autogenous bone and as a biologic membrane over the bone grafted alveolar cleft was used. results:  autogenous bone in all (four cases) was...

introduction based on previous researches, dental pulp stem cells (dpscs) are easily accessible with limited morbidity after collection. their embryonic origin, from neural crests, explains their multipotency. dpscs are primarily derived from the pulp tissues of the teeth.objective: this study was undertaken to isolate, culture, and characterize two different third molar and first premolar huma...

background  many biomaterials are used during the open sinus lift surgery, beneath the elevated scheniderian membrane and maxillary sinus bony floor but the search for ideal material continues. methods  in the maxillary posterior atrophic ridges with the bone height less than four millimeters the open sinus lift surgery performed. the autologous platelet-rich plasma (prf) was used as the sole g...

background stem cell transplantation has become as a novel treatment  for end-stage kidney, lung, heart , liver diseases and several hematologic disorders. improved survival of transplant recipients has raised awareness of post-transplant complications. one of these complications is transplant-related osteoporosis. methods  in this manuscript we review prevention methods for transplant-related ...

background cancer stem cells play crucial roles in resistance to therapeutic schemes and relapse of disease, so it is important to find targeted therapies that kill them selectively. breast cancer is the most common cancer in females living in all part of the world including iran and it has an important burden in public health with direct impact on patients’ families. breast cancer in young adu...

background  isolation of adipose tissue mesenchymal stem cells (mscs) with current enzymatic methods has some limitations. for example, it is costly and time-consuming and results in a heterogeneous cell population that making compromise proliferation and differentiation of mscs. also, it is accompanied with the increased risk of culture contaminations because of several handling steps.in this ...

background mandibular continuity defects occur after tumor resection, maxillofacial injury, or osteomyelitis. despite the current availability of a plethora of treatment modalities, bone substitutes, and various clinical adjuncts, an exact reconstructive recapitulation of large bony defects continues to be beyond reach. in this clinical pilot study, we report a novel method for reconstruction o...