objective: common variable immunodeficiency (cvid) is one of the most frequent cases of primary immunodeficiency. it is likely that this heterogeneous disease is caused by several distinct genetic disorders. the activation-induced cytidine deaminase (aid) enzyme is involved in class switching, somatic hypermutation (shm) and processes associated with gene conversion in the germinal center. in o...

Two-phase single-case designs, including baseline evaluation followed by an intervention, represent the most clinically straightforward option for combining professional practice and research. However, unless they are part of a multiple-baseline schedule, such designs do not allow demonstrating a causal relation between the intervention and the behavior. Although the statistical options reviewe...

In Sub-Saharan Africa, 40% of the burden of disease and injury can potentially be addressed by emergency care. Adequate pre-hospital care is vital, but often unavailable in Sub-Saharan Africa. Initial help and emergency transport often depends on basic first responders. The World Bank identified first aid training as cost-effective way to save lives in Sub-Saharan Africa. Although well-intentio...

The methods used at the Clinical Research Centre, Northwick Park Hospital, to treat wounds potentially infected with neurotropic viruses are outlined. Emphasis is laid on first aid and on surgical attention. Patients should remain under medical supervision for at least four weeks after the injury, the need for specific post-exposure treatment depending on the nature of the exposure.

We calculate momentum transport from tearing fluctuations in a reversed field pinch with sheared flow, considering both the effect of a single tearing mode (through quasilinear theory and MHD computation) and multiple tearing modes (through nonlinear MHD computation). A single tearing mode transports momentum, via Maxwell and Reynolds stresses, more rapidly than classical viscous forces. Moreov...

BACKGROUND Anecdotal evidence reported an outbreak of symptoms on Fraser Island during the late 1990 s similar to those expected from exposure to dermotoxins found in the cyanobacterium L. majuscula. This coincided with the presence of a bloom of L. majuscula. METHODS Records from the Fraser Island National Parks First aid station were examined. Information on cyanobacterial blooms at Fraser ...

In England and Wales, 53% of live births were born within marriage in 2013, compared to 59% in 2003 and 93% in 1963 [1] . The average age at marriage has increased and more children are born to women older than 30 years. In the UK, there were 2.0 million lone parents with dependent children in 2015. This figure has grown steadily from 1.9 million in 2005. Lone parents with dependent children re...

The problem for consistency between linear transports along paths and real bundle metrics in real vector bundles is stated. Necessary and/or sufficient conditions, as well as conditions for existence, for such consistency are derived. All metrics (resp. transports) consistent with a given transport (resp. metric) are explicitly obtained. The special case of linear transports, generated by deriv...

This paper discusses the use of general principles that are used to promote usability in interactive systems. These interactive systems include some commercially software applications, computing devices, and interfaces. First, a summary of those principles is provided. Then, six detailed examples from the chosen application(s), device(s), and interface(s) are discussed, two for each principle. ...

This paper investigates whether an outcome-based aid formula can improve fiscal and outcome equity across local school districts more strongly than a typical aid formula does, including Ohio’s recent aid formula. When the outcome-based aid formula is applied to foundation aid, fiscal and outcome equity deteriorates compared with the Ohio’s recent aid formula. However, when it is applied to powe...