Abstract Background Mesenchymal stem cell treatments in dogs have been investigated as a potential innovative alternative to current conventional therapies for variety of conditions. So far, the precise mode action MSCs has yet be determined. The aim this study was gain more insights into pharmacokinetics by evaluating their biodistribution healthy after different injection routes. Methods Thre...

Suspicion for Cardiac Amyloidosis (CA) led a 75-year-old male patient with fatigue, dyspnea, and palpitations to be subjected scintigraphic myocardial investigation technetium-99m-pyrophosphate (99mTc-PYP, or PYP scan) in order distinguish transthyretin-related CA (ATTR) from the light-chain (AL) form. A characteristic anamnesis of bilateral carpal tunnel syndrome, vertebral canal stenosis, sen...

Particulate air pollution is associated with respiratory and cardiovascular morbidity and mortality. Recent studies investigated whether and to which extent inhaled ultrafine particles are able to translocate into the bloodstream in humans. However, their conclusions were conflicting. We developed a physiologically based kinetic model for (99m)technetium-labelled carbon nanoparticles (Technegas...

Abstract Background The digital cadmium–zinc–telluride (CZT)-based SPECT system has many advantages, including better spatial and energy resolution. However, the impacts of different acquisition reconstruction parameters on CZT quantification might still need to be validated. This study aimed evaluate (the main window time per frame) number iterations, subsets in iterative reconstruction, post-...

BACKGROUND Because of the need to limit side-effects, nanoparticles are increasingly being studied as drug-carrying and targeting tools. We have previously reported on a scheme to produce protein-based self-assembling nanoparticles that can act as antigen display platforms. Here we attempted to use the same system for cancer-targeting, making use of a C-terminal bombesin peptide that has high a...

UNLABELLED To visualize the regional localization of glutathione (GSH) in the brain, the relationship between the concentrations of tissue GSH and uptake of [99mTc]meso-hexamethyl propyleneamine oxime ([99mTc] meso-HMPAO) or [99mTc]d,l-hexamethyl propyleneamine oxime ([99mTc]d,l-HMPAO) was studied in mice. METHODS The uptake of [99mTc]meso-HMPAO in the mouse brain was decreased to 35% of cont...

The distribution of creatinine, one of the toxic guanidine compounds, in various tissues has not been studied in detail by using radiolabeled creatinine. Our objective was to investigate the biodistribution of creatinine labeled with 99m technetium (99mTc) by the stannous (II) chloride method in healthy male Wistar rats. Quality controls were carried out by radio thin layer chromatography, high...