Two potentially tripodal ligands, tris(1-phenyl-1H-1,2,3-triazol-4-yl)phosphine oxide (OP(1,2,3Tz1?Ph)3) and tris(1-benzyl-1H-1,2,3-triazol-4-yl)phosphine (OP(1,2,3Tz1?benz)3), were used in reactions with [Re(CO)5Br] (NEt4)2[Tc(CO)3Cl3]. While the formation of rhenium complexes bidentate tridentate coordinated phosphine oxides was observed, for technetium only cationic OP(1,2,3Tz1?R) ligands is...

The aim of this work was to prepare a kit of Tc-ceftizoxime (Tc-CFT), with stability and biological activity preserved, able to identify a septic focus (E. coli) in the experimental infection model in rats. The preparation of the CFT kit involved the use of lyophilized solutions containing the antibiotic ceftizoxime and the sodium dithionite reducing agent (6.0 mg/mL). After lyophilization, the...

A series of five glucosamine-conjugated organometallic complexes of the tricarbonyl cores of technetium-99m and rhenium were made. Glucosamine was derivatized at the C-2 nitrogen with long chain alkyl spacers linked to either pyridyl-tert-nitrogen-phenol tridentate chelates or cyclopentadienyl ligating groups. The metal complexes of the tridentate ligands were formed by refluxing with [Re(CO)(3...

Radionuclide myocardial perfusion imaging in conjunction with exercise or pharmacologic stress testing is an established technique for diagnosing and assessing the severity of coronary artery disease (1 ). Currently TI is the most widely used radiopharmaceutical for myocardial perfusion imaging. Thallium-201, however, has disadvantages such as low photopeak energy (69-83 keV), which can cause d...