OBJECTIVE: The purpose of this study was to ascertain the extent which ocular surface women with polycystic ovary syndrome is impacted. STUDY DESIGN: Included in case-control were 23 eyes patients (Group I) and 10 healthy subjects II). Polycystic diagnosed when two following conditions met: oligo- or anovulation, clinical and/or biochemical signs hyperandrogenism, ultrasonographic documentation...

PURPOSE Protein kinase C (PKC) α plays a major role in the parasympathetic neural stimulation of lacrimal gland (LG) secretion. It also has been reported to have antiapoptotic properties and to promote cell survival. Therefore, the hypothesis for the present study was that PKCα knockout ((-/-)) mice have impaired ocular surface-lacrimal gland signaling, rendering them susceptible to desiccating...

BACKGROUND The objectives of this study were to develop stable cyclosporine A (CsA) ophthalmic micelle solutions for dry-eye syndrome and evaluate their physicochemical properties and therapeutic efficacy. MATERIALS AND METHODS CsA-micelle solutions (MS-CsA) were created by a simple method with Cremophor EL, ethanol, and phosphate buffer. We investigated the particle size, pH, and osmolarity....

PURPOSE The differential diagnosis of dry eye syndrome is still a challenging task. The purpose of this study was to understand the relationship between a novel, objective clinical parameter, the "corrected lipid layer stabilization time," and commonly performed clinical tests for dry eye patients. METHODS Data were obtained from a prospective clinical study with 59 patients of different subj...

Dry eye syndrome (DES) is a common eye disease. Artificial tears (AT) are used to treat DES, but they are not effective. In this study, we assessed the anti-inflammatory effect of AT containing epigallocatechin gallate (EGCG) and hyaluronic acid (HA) on DES. Human corneal epithelial cells (HCECs) were used in the WST-8 assay to determine the safe dose of EGCG. Lipopolysaccharide-stimulated HCEC...

Purpose To determine the effectiveness of Aurai water propelled, heating Eye Massager (AEM) in managing dry eye disease and its effects on ocular adnexa. Methods This prospective, randomised cross-over study enrolled 15 participants (aged 25.8 ± 5.45 years, 5 male). Participants wore a smart watch 24 h day to track their sleeping cycle heart rate for 4 weeks, using AEM twice 2 those weeks. A 6 ...