نتایج جستجو برای: taybi syndrome

تعداد نتایج: 621935  

2017
Yasamin Olyaei J. Manuel Sarmiento Serguei I Bannykh Doniel Drazin Robert T Naruse Wesley King

Rubinstein-Taybi Syndrome (RSTS) is an autosomal dominant disorder that is classically characterized by prenatal and postnatal growth restriction, microcephaly, dysmorphic craniofacial features, broad thumbs and toes, and intellectual disability. We describe the first reported case of a pituitary macroadenoma associated with RSTS. A 39-year-old Caucasian female with a past medical history of RS...

2018
Max V Boot Martine J van Belzen Lucy I Overbeek Nathalie Hijmering Matias Mendeville Quinten Waisfisz Pieter Wesseling Raoul C Hennekam Daphne de Jong

Rubinstein-Taybi syndrome (RSTS) is a multiple congenital anomalies syndrome associated with mutations in CREBBP (70%) and EP300 (5-10%). Previous reports have suggested an increased incidence of specific benign and possibly also malignant tumors. We identified all known individuals diagnosed with RSTS in the Netherlands until 2015 (n = 87) and studied the incidence and character of neoplastic ...

Journal: :American journal of medical genetics. Part A 2015
Benjamin D Solomon Dale L Bodian Alina Khromykh Gabriela Gomez Mora Brendan C Lanpher Ramaswamy K Iyer Rajiv Baveja Joseph G Vockley John E Niederhuber

Rubinstein-Taybi syndrome (RSTS) can be caused by heterozygous mutations or deletions involving CREBBP or, less commonly, EP300. To date, only 15 patients with EP300 mutations have been clinically described. Frequently reported manifestations in these patients include characteristic facial and limb features, varying degrees of neurocognitive dysfunction, and maternal preeclampsia. Other congeni...

Journal: :Indian Journal of Physical Medicine and Rehabilitation 2017

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