A rapid and sensitive liquid chromatography–tandem mass spectrometry (LC-MS) method for the estimation of enalapril and enalaprilat in human plasma. Detection of analytes was achieved by tandem mass spectrometry with electrospray ionization (ESI) interface in positive ion mode was operated under the multiple-reaction monitoring mode. Sample pretreatment involved in a one-step protein precipitat...

Physical, chemical and biological attributes of soil surface are significantly affected by tillage practices and crop rotation. The objective of this study was to determine the short-term (2006-2009) effects of conventional and conservational tillage practices on selected soil physical properties of a heavy clay soil under two wheat-corn and wheatlegume rotation in a semi-arid Mediterranean...

An open-label, single-dose, randomized, 2-way crossover study was conducted in fasted healthy Iranian male volunteers. Eligible participants randomly assigned in a 1:1 ratio to be given one tablet of the test or reference formulation, followed by a 2-week washout period and administration of the exchange formulation. A quick and susceptible Liquid Chromatography–tandem Mass Spectro...

Objective(s): Human gastrointestinal tract harbors a variety of bacteria with vital roles in human health. Bacteroides fragilis is considered one of the dominant constituents of gut microflora which can act as an opportunistic pathogen leading to various diseases, including colon cancer, diarrhea, uterine and intrathecal abscesses, septicemia, and pelvic inflammation. ...

A tandem, one vehicle per loop, approach to Automated Guided Vehicle System (AGVS) guide path design has been proposed as a more efficient and flexible alternative to traditional AGV system design. The tandem design can substantially simplify the design task while providing even further flexibility for changes in production system layout and operation. Tandem guide paths, however, have potentia...

A tandem array is a substring of the form k x , where x is any unspecific substring and k is at least two (when k is 2, 2 x is also called a tandem repeat or square). A non-extendable tandem array occurring in string S is a tandem array k x which are not followed or preceded by another occurrence of x in S. The problem of this thesis is defined as follows: Given a string S of length n, find all...

Somatic mutations in the mitochondrial DNA (mtDNA) displacement loop (D-loop) region have been frequently detected in various human cancers. In a previous study, we identified a polyplasmic 260-bp tandem duplication and triplication mutation in the mtDNA D-loop of one gastric cancer. In the present study, we adopted a more sensitive back-to-back polymerase chain reaction method to screen for th...

Tandem constructs are increasingly being used to restrict the composition of recombinant multimeric channels. It is therefore important to assess not only whether such approaches give functional channels, but also whether such channels completely incorporate the subunit tandems. We have addressed this question for neuronal nicotinic acetylcholine receptors, using a channel mutation as a reporte...

Tandem and segmental duplications significantly contribute to gene family expansion and genome evolution. Genome-wide identification of tandem and segmental genes has been analyzed before in several plant genomes. However, comparative studies in functional bias, expression divergence and their roles in species domestication are still lacking. We have carried out a genome-wide identification and...