Objectives: The aim of the study is to evaluate antidepressant activity ethanolic extract leaves Moringa oleifera L. (EEMO) on albino mice. Methods: anti-depressant was evaluated using forced swimming test (FST) and tail suspension (TST). Healthy mice were individually swim inside a vertical glass cylinder. Climbing, swimming, immobility tested recorded. In TST, suspended string held by metal s...

background and objective: hyperalgesia is one of the marked clinical signs of patients with diabetes mellitus that affects their lifestyle. this study was conducted to assess the anti-nociceptive effect of chronic administration of curcumin in streptozotocin (stz)-diabetic rats using formalin, hot tail immersion, and paw pressure tests. materials and methods: this study was conducted on 40 male...

Beta-Ca2+/calmodulin-dependent protein kinase II (βCaMKII) is known as a powerful regulator of lateral habenula neuron function and key molecular determinant depression. βCaMKII also abundant in the hippocampus, especially dentate gyrus (DG). However, whether DG involved emotional behaviors remains unknown. In this study, using βCaMKII-F90G transgenic mice, which overexpression restr...

Objective: Pimpinella anisum (P. anisum) has different pharmacological properties such as anticonvulsant, analgesic, tranquilizer, antidepressant and anti-anxiety effects. In this study the antidepressant-like effect of aqueous and ethanolic extracts of P. anisum fruit in mice was investigated. Materials and Methods: Forced swimming test (FST) and tail suspension test (TST) were used to determ...

Objective: The present study was designed to investigate the putative antidepressant effects of crocin and crocetin, two major active ingredients of Crocus sativus L. (saffron) using mice in two different regimens of acute and sub-acute administration. Material and Methods: In acute treatment, antidepressant-like activities of crocin and crocetin (10, 20 and 40 mg/kg, i.p.) were evaluated using...

Objective: The goal of this study is to find out how Fragaria Ananassa (strawberries) affects serotonin levels and mouse immobility duration during the different tests performed in mice evaluate antidepressant effects FragariaAnanassa. Methods: Antidepressant compared with Standard drugs by performing a Forced Swim Test Tail Suspension on albino mice. was administered two distinct groups animal...

Background Z-guggulsterone, an active compound extracted from the gum resin of the tree Commiphora mukul, has been shown to improve animal memory deficits via activating the brain-derived neurotrophic factor signaling pathway. Here, we investigated the antidepressant-like effect of Z-guggulsterone in a chronic unpredictable stress mouse model of depression. Methods The effects of Z-guggulster...

OBJECTIVE Aim of this study was to identify whether docosahexaenoic acid (DHA) has a vital antidepressant by hypothalamic-pituitary-adrenal axis (HPA axis) or not. METHODS Mice were divided into 2 groups: control group and DHA dietary group. DHA dietary group was treated with DHA dietary everyday for consecutive 50 days. The forced swimming test and tail suspension test were conducted. Hypoth...

Skeletal unloading induces trabecular bone loss in loaded bones. The tail-suspended mouse model simulates conditions associated with lack of mechanical stress such as space flight for the loaded bones. In such a model, the tail supports the body weight. The forelimbs are normally loaded and the movement of its hindlimbs is free without weight bearing. Histomorphometric analyses of the murine ti...