nicotinic ligands have been studied as novel therapeutic interventions in pain therapeutics since a long time. several nicotinic agonists have been withdrawn from later stages of clinical trials due to lack of efficacy or narrow therapeutic window. these have been documented to act in the central nervous system and produce a wide range of pharmacological effects, including memory enhancing and ...

Rhodiola rosea L. (Crassulaceae) have been used as traditional medicines that can increase someone’s physical strength, work productivity, longevity and resistance to high altitude sickness, fatigue, depression, anaemia, gastrointestinal ailments, infections, and nervous system disorders. The objective of this study was to evaluate the anti-inflammatory and analgesic activities from the methano...

In the present study, we evaluate the analgesic activity of methanolic extract obtained from Jatropha unicostata balf leaves, using chemical and thermal models which will induce acute pain in mice and rats. This study was carried out by using sex Swiss mice (20-30gm) and wistar male rats (200-250gm).The methanolic extract was prepared by using maceration at room temperature (25°) over the perio...

— Conventional Augmented Reality has used data gloves or markers for smooth interaction between objects and background. This causes inconvenience of use and lower immersion. To build up immersion in Augmented Reality, additional input devices must be removed. For this purpose, accurate recognition of space coordinates is needed even with no attachment of markers. This paper proposes a method to...

it is generally believed that unaccustomed exercise causes myofibrillar damage. in recent years, cold water immersion (cwi) following heavy training sessions and matches has been common aiming at reducing soreness. however, there is no strong scientific rationality if this method really accelerates recovery after exercise. in addition, there is a question that if it is possible for this method ...

The ethanol and water extracts of Sansevieria trifasciata leaves showed dose-dependent and significant (P < 0.05) increase in pain threshold in tail-immersion test. Moreover, both the extracts (100 - 200 mg/kg) exhibited a dose-dependent inhibition of writhing and also showed a significant (P < 0.001) inhibition of both phases of the formalin pain test. The ethanol extract (200 mg/kg) significa...

The objective of this paper was to study the anti-inflammatory and analgesic effects of Radix Angelicae Pubescentis (R.A.P) ethanol extracts. Three classic anti-inflammatory models and two analgesic models were used in this research. In anti-inflammatory tests, all the extracts have a certain inhibition on the acute inflammation induced by xylene, however, 60% ethanol extract significantly inhi...

Background and Objective: Hyperalgesia is one of the marked clinical signs of patients with diabetes mellitus that affects their lifestyle. This study was conducted to assess the anti-nociceptive effect of chronic administration of curcumin in streptozotocin (STZ)-diabetic rats using formalin, hot tail immersion, and paw pressure tests. Materials and Methods: This study was conducted on 40 male...

We previously developed a water immersion (“underwater”) technique for endoscopic submucosal dissection (ESD) to reduce adverse events [1,2]. We herein present a novel method of gel immersion ESD with the advantages of underwater ESD. We used a gel-type oral rehydration solution (OS-1 Jelly; Otsuka Pharmaceutical Factory, Tokushima, Japan) with balanced electrolytes and carbohydrates. Bipolar e...