Combretastatin A4 disodium phosphate (CA4DP) is a prodrug of combretastatin (CA4), microtubule-disassembling agent that exhibits antitumor effects by inhibiting tumor cell proliferation and inducing morphological changes apoptosis in vascular endothelial cells tumors. However, cardiotoxicity induced ischemia hypertension severe adverse event. In this study, we focused on the fact phosphodiester...

Introduction Acute urinary retention (AUR) is known to have major impact on the quality of life and sexuality patients with benign prostatic hyperplasia (BPH). However, little about specific approachs that could reduce this impact. Tadalafil, an efficient medication in uncomplicated BPH, may be also useful serious complications, especially AUR. Objectives The aim study assess Tadalafil AUR rela...

10.2217/14750708.5.3.355 © 2 In the aging male, erectile dysfunction (ED) and lower urinary tract symptoms (LUTS) are common conditions that have been shown to be related. As life expectancy increases, treatments that target both ED and LUTS will prove increasingly valuable over the coming years. Phosphodiesterase type 5 (PDE5) inhibitors are used primarily to treat ED. Recently, studies have s...

A recently published paper addressed the interesting topic of prevention of erectile dysfunction (ED) with tadalafil, a phosphodiesterase-type 5 inhibitor (PDE5i) in patients undergoing radiation therapy for localized prostate cancer. Tadalafil 5 mg or placebo was administered once-daily for 24 weeks in patients undergoing external-beam radiotherapy (EBRT) or brachytherapy (BT) for prostate can...

Two simple and sensitive UV-Visible spectrophotometric methods A and B for the determination of tadalafil have been described. These methods are based on the formation of bluish green color and blue colored chromogens obtained when the drug was condensed with Isatin and Xanthydrol exhibiting λmax at 665 and 640nm respectively. These methods obey Beer’s Law in the concentration ranges of 0.4-2.0...

A simple, rapid, accurate, and selective quantitative nuclear magnetic resonance method for the determination of tadalafil in bulk drugs and its tablets was established and evaluated. Spectra were obtained in dimethylsulfoxide-d6 using 2,4-dinitrotoluene as the internal standard. In this study, the method's linearity, range, limit of quantification, stability, precision, and accuracy were valid...

A tadalafil analogue was detected in a dietary supplement marketed for tonic effect, along with hydroxyhomosildenafil and aminotadalafil. The tadalafil analogue was isolated by preparative thin layer chromatography (TLC) and its structure was elucidated using high-performance liquid chromatography (HPLC), liquid chromatography electrospray ionization-mass spectrometry (LC-ESI-MS), Fourier trans...

Background Our laboratory has shown that phosphodiesterase-5 (PDE-5) inhibitors including sildenafil, vardenafil and tadalafil induce powerful protection against myocardial ischemia-reperfusion injury. We have shown that sildenafil protects through activation PKC, expression of eNOS/ iNOS, protein kinase G (PKG) and opening of mitochondrial KATP (mitoKATP) channels [1]. Hydrogen sulfide (H2S) i...

Tadalafil is a clinically approved phosphodiesterase-5 inhibitor for the treatment of erectile dysfunction and pulmonary arterial hypertension. It contains two chiral carbons, and the marketed isomer is the 6R, 12aR isomer with a methyl substituent on the terminal nitrogen of the piperazinedione ring. In this report, tadalafil analogues with an extended hydrophilic side chain on the piperazine ...

Radical prostatectomy (RP) is preferred for many patients with clinically localized prostate cancer. Despite the introduction of the nerve sparing technique and progressive modifications on RP, postoperative preservation of penile erectile function remains a challenge to urologists. Earlier initiation of penile rehabilitation can significantly improve the patient's quality of life affected by e...