Background: We conducted a narrative review of studies analyzing the occlusal and mandibular plane angles after maxillary molar distalization using temporary skeletal anchorage devices (TADs). An original preliminary investigation was on angle changes according to design TAD-supported distalization. Methods: included 51 participants stratified into three groups (buccal TAD, lingual arch pendulu...

The Rel/NFB transcription factors are constitutively activated in many human cancers. The Rel proteins in this family are implicated in leukemia/lymphomagenesis, but the mechanism is not completely understood. Previous studies showed that the transcription activation domains (TADs) of the viral oncoprotein v-Rel and its cellular Rel/NFB homologues c-Rel and RelA are key determinants of their di...

Several subclasses of type IV pili have been described according to the characteristics of the structural prepilin subunit. Whereas molecular mechanisms of type IVa pilus assembly have been well documented for Pseudomonas aeruginosa and involve the PilD prepilin peptidase, no type IVb pili have been described in this microorganism. One subclass of type IVb prepilins has been identified as the F...

Objective: To develop factors based on the Autism Diagnostic Interview-Revised (ADI-R) that index separate components of the autism phenotype that are genetically relevant and validated against standard measures of the constructs. Method: ADIs and ADI-Rs of 292 individuals with autism were subjected to a principal components analysis using VARCLUS. The resulting variable clusters were validated...

Several authors have described anatomic variations of the aortic arch in 13% to 20% of the patients who do not have aortic disease. However, few studies have evaluated these patterns in the thoracic aortic dissection (TAD). In the authors' knowledge, this is the first survey that specifically investigates the frequency of these variations in a broad, nonselected group of Chinese patients with a...

In this issue of Blood, Lokhorst and colleagues report on the results of HOVON-50, a phase 3 randomized trial designed to evaluate the effects of thalidomide during induction treatment and as maintenance in patients with multiple myeloma. There were 556 patients randomly assigned either to 3 cycles of VAD or to TAD. All patients were to receive high-dose melphalan with autologous stem cell supp...

To evaluate a new technique of Dynamic hip screw (DHS) fixation without using traction table. From july 2006 to july 2012, 328 patients undergoing DHS fixation using manual traction technique were evaluated in terms of Tip apex distance (TAD), -quality of fracture reduction, operation time, preoperative preparation time. In 97% cases good to moderate reduction could be achieved. The mean TAD wa...

Dual and triple activity-difference (DAD/TAD) maps are twoand threedimensional representations of the pairwise activity differences of compound data sets, respectively [1]. These maps are valuable tools for the systematic characterization of structure-activity relationships (SAR) of compounds data sets screened against two or three targets [2]. Adding pairwise structural similarity information ...

BACKGROUND Descending thoracic aortic aneurysm and dissection (DTAAD) is characterized by progressive medial degeneration, which may result from excessive tissue destruction and insufficient repair. Resistance to tissue destruction and aortic self-repair are critical in preventing medial degeneration. The signaling pathways that control these processes in DTAAD are poorly understood. Because No...