BACKGROUND AND PURPOSE Generic utility health-related quality of life instruments are useful in assessing stroke outcome because they facilitate a broader description of the disease and outcomes, allow comparisons between diseases, and can be used in cost-benefit analysis. The aim of this study was to validate the Assessment of Quality of Life (AQoL) instrument in a stroke population. METHODS...

Cyclic AMP is a major trigger of the differentiation process of Trypanosoma brucei, a bloodstream parasite causing sleeping sickness. Its generation in trypanosomes is accomplished by a unique battery of membrane-bound adenylate cyclases (ACs). We have determined the high-resolution X-ray structures of the catalytic domains of two trypanosomal ACs (tACs), GRESAG4.1 and GRESAG4.3. The tAC domain...

We analysed the extent to which European politicians have adhered to scientific recommendations on annual total allowable catches (TACs) from 1987 to 2011, covering most of the period of the Common Fisheries Policy (CFP). For the 11 stocks examined, TACs were set higher than scientific recommendations in 68% of decisions. Politically-adjusted TACs averaged 33% above scientifically recommended l...

Tinnitus is the perception of a sound in the absence of an external acoustic source, which often exerts a significant impact on the quality of life. Currently there is evidence that neuroplastic changes in both neural pathways are involved in the generation and maintaining of tinnitus. Neuromodulation has been suggested to interfere with these neuroplastic alterations. In this study we aimed to...

We discovered by using high resolution video microscopy, that membranes become attached selectively to the growing plus ends of microtubules by membrane/microtubule tip attachment complexes (TACs) in interphase-arrested, undiluted, Xenopus egg extracts. Persistent plus end growth of stationary microtubules pushed the membranes into thin tubules and dragged them through the cytoplasm at the appr...

This work has been undertaken to evaluate the accuracy of 3-D dynamic simulations in neurological imaging protocols with positron emission tomography (PET). We used [18F] uorodopa PET images from a pair of normal brain and Parkinsonian brain. Spatially correlated MR images were segmented into several tissue types and anatomical structures. Voxels within every structure were assigned with the ti...

BACKGROUND  Several criteria exist to identify the optimal model for quantification of tracer kinetics. The purpose of this study was to evaluate the correspondence in kinetic model preference identification for brain PET studies among five model selection criteria: Akaike Information Criterion (AIC), AIC unbiased (AICC), model selection criterion (MSC), Schwartz Criterion (SC), and F-test. M...

This paper introduces a novel (bi)simulation{based faster{than preorder which relates asynchronous processes with respect to their worst{case timing behavior. The studies are conducted for a conservative extension of the process algebra CCS, called TACS, which permits the speci cation of maximal time bounds of actions. TACS complements work in plain process algebras which compares asynchronous ...

Technical Aid Centers (TACs) in Norway supply devices, such as wheelchairs and hearing aids, to people with handicaps. When a device is returned to a TAC, the TAC staff must decide whether to scrap it or to refurbish it so that it can be used again. The Norwegian National Insurance Administration (NNIA) found that decision makers were scrapping units too frequently, basing their decisions mainl...