Abstract Chimeric antigen receptor (CAR)-T cell therapy is a promising treatment for lymphoblastic leukemia and lymphoma. Despite initial response to CAR-T therapy, about 40% of patients relapse. Modulating metabolism (immunometabolism) being considering as novel approach improve efficacy. We have identified MCJ (DnaJC15) target enhance mitochondrial metabolism. an endogenous negative regulator...

background: mature t/ nk-cell neoplasms are a rare group of disorders and their presentation as leukemia is even rarer. most of the previous studies have focused on mature b-cell lineage leukemias and there is a paucity of data on mature t/nk-cell lineage leukemias. we, therefore, planned this study to analyze their spectrum, frequency, morphology and immunophenotypic features. methods: all cas...