Recent studies have demonstrated that β-catenin in DCs serves as a key mediator in promoting both CD4(+) and CD8(+) T-cell tolerance, although how β-catenin exerts its functions remains incompletely understood. Here we report that activation of β-catenin in DCs inhibits cross-priming of CD8(+) T cells by up-regulating mTOR-dependent IL-10, suggesting blocking β-catenin/mTOR/IL-10 signaling as a...

This is an expository note on Fedosov’s construction of deformation quantization. Given a symplectic manifold and a connection on it, we show how to calculate the star-product step by step. We draw simple diagrams to solve the recursive equations for the Fedosov connection and for flat sections of the Weyl algebra bundle corresponding to functions. We also reflect on the differences of symplect...

Here t ≥ 0, wt is a standard d-dimensional Wiener process, coordinated as usual with some rightcontinuous non-decreasing flow of σ-algebras Ft ⊂ F ; fi and βi are nonrandom functions with respective values in R and R, (here and elsewhere i = 1, 2). The random vectors ai are measurable with respect to the σ-algebra F0 and ai ∈ Q̄ with probability 1(Q̄ denotes the closure of the region Q ). All vec...

In top-down proteomics, intact gaseous proteins are fragmented in a mass spectrometer by, e.g., electron capture dissociation (ECD) to obtain structural information. By far, most top-down approaches involve dissociation of protein cations. However, in electrospray ionization of phosphoproteins, the high acidity of phosphate may contribute to the formation of intramolecular hydrogen bonds or sal...

We introduce a cut-balance condition for continuous time consensus seeking systems, which generalizes weak forms of symmetry and of average preservation. We show that, if a system satisfies the cut balance condition, it always converges to a set of clusters, and we characterize the clusters in terms of the graph describing the infinite interactions between the agents. We consider continuous-tim...

Let D(U1, U2, ..., Uk) be an oriented k -partite graph with |Ui| = ni, 1 ≤ i ≤ k. Then, the score of a vertex ui in Ui is defined by aui (or simply ai ) = ∑k t=1, t 6=i nt+d + ui −d − ui , where d+ui and d − ui are respectively the outdegree and indegree of ui. The set A of distinct scores of the vertices of D(U1, U2, ..., Uk) is called its score set. In this paper, we prove that if a1 is a non...

In this lecture, we develop the notion of “adaptive learning” as proposed by Milgrom and Roberts [1]. Although the learning definition they give is of interest in its own right, it primarily derives power in the case of dominance solvable games, or for games where there is a straightforward characterization of the set of strategies surviving iterated strict dominance (hereafter ISD). Throughout...

Recent studies have suggested that rheological mechanisms may be involved in the pathogenesis of ischemic syndromes in hyperlipidemias. We investigated the association between erythrocyte aggregation and components of lipoproteins in the blood of 60 normotensive, hypercholesterolemic men aged 45 +/- 8 years. The rheological parameters assessed were aggregation index (AI) and disaggregation shea...

In this paper we propose new key agreement protocols based on multivariate polynomials over finite field Fq. We concretely generate the multivariate polynomial F(X)∈Fq[x1,..,xn] such that F(X)=Σi=1 m ki[Ai(X) d + Ai(X) d-1 + ..+ Ai(X)] where Ai(X) =ai1x1+...+ainxn ,coefficients ki , aij ∈ Fq (i=1,..,m:j=1,..,n) and variables X=(x1,..,xn) T ∈ Fq[x1,..,xn] . The common key K(X) has the form such ...