Systemic sclerosis (SSc) is a rare chronic autoimmune disease characterized by vasculopathy, dysregulation of innate and adaptive immune responses, progressive fibrosis. SSc remains an orphan disease, with high morbity mortality in patients. The mesenchymal stromal cells (MSC) demonstrate vitro vivo pro-angiogenic, immuno-suppressive, anti-fibrotic properties appear as promising stem cell thera...