Invasive fungal infections are a major challenge in the management of immunocompromised patients and those with renal dysfunction. These challenges are due to the immense morbidity and mortality in such situations. Also the management strategies for invasive mycosis in patients with renal dysfunction have narrow safety profile and involve high-cost. In this review we will discuss the issues inv...

BACKGROUND AND OBJECTIVE Analysis of inflammatory biomarkers in saliva could offer an attractive opportunity for the diagnosis of different systemic conditions specifically in epidemiological surveys. The aim of this study was to investigate if certain salivary biomarkers could be used for detection of common systemic diseases. MATERIALS AND METHODS A randomly selected sample of 1000 adults l...

The systemic fungus diseases are not common, and it is difficult to amass a significant number of patients with anyone specific deep mycosis in order to evaluate clinically any new chemotherapeutic agent. This review has attempted to assemble and summarize the present-day knowledge of the newer antifungal agents. Individual consideration is given to the systemic fungus diseases: coccidioidomyco...

The risk of cardiovascular (CV) events and mortality is significantly higher in patients with systemic rheumatic diseases than in the general population. Although CV involvement in such patients is highly heterogeneous and may affect various structures of the heart, it can now be diagnosed earlier and promptly treated. Various types of assessments are employed for the evaluation of CV risk such...

We have reviewed scientific literature about the association of systemic sclerosis (SSc) and thyroid disorders. A high incidence, and prevalence, of new cases of autoimmune thyroiditis (AT) and/or hypothyroidism have been shown in sclerodermic patients (overall in the female gender). An association among a Th1 immune-predominance, low vitamin D levels, and AT have been also shown in SSc patient...

INTRODUCTION The incidence of depression accompanying medical pathologies is elevated and have prognostic importance. OBJECTIVE To determine the frequency of depression in patients with systemic autoimmune diseases (SAD), as well as to determine the frequency of pain, fatigue and sleep disorders in these patients and their relation with depression. MATERIAL AND METHODS We performed a descri...

REVISTA ESPAÑOLA DE CARDIOLOGÍA ha sido tradicionalmente uno de los principales motores de la difusión del conocimiento cientı́fico en el ámbito de la cardiologı́a. La educación médica continuada ha sido uno de los pilares en el desarrollo demuchas de las sociedades cientı́ficas más importantes en nuestros dı́as. Para lograr ese objetivo, se han empleado diversos medios, entre los que destacan los ...

Inflammation of the eye is often times seen in association with systemic inflammatory diseases. Understanding the various forms of ocular involvement in these conditions is important as untreated ophthalmic involvement can lead to severe vision loss. In addition to providing a basic framework for diagnosis and treatment, this review will highlight the ocular manifestations of the following syst...

Inflammatory diseases of the CNS blood vessels are a large heterogeneous group with multiple causes sharing certain pathological features, particularly intramural inflammation and necrotic changes within the vascular wall. Unlike infectious vasculitides secondary to direct infection of blood vessels by organisms, non-infectious CNS vasculitides appear to result from immunological injury. Noninf...