There are various subgroups of patients with metastatic prostate cancer: polymetastatic, oligometastatic, or oligo-recurrent cancers whose progression follows different courses and for whom there are different treatment options. Knowledge of tumor dissemination pathways and different genetic and epigenetic tumor profiles, as well as their evolution during disease progression, along with new dia...

An oral medicine doctor is trained to diagnose and manage patients with disorders of the orofacial region, essentially as a "physician mouth." has received additional specialized training experience in diagnosis management mucosal abnormalities (growths, ulcers, infection, allergies, immune-mediated autoimmune disorders, cancers), salivary gland temporomandibular (e.g.: problems TMJ) facial pai...

The notion of entropy is used to compare the complexity associated with 12 common cancers based on metastatic tumor distribution autopsy data. We characterize power-law distributions, entropy, and Kullback-Liebler divergence associated with each primary cancer as compared with data for all cancer types aggregated. We then correlate entropy values with other measures of complexity associated wit...

Nasopharyngeal cancer is unique among head and neck cancers. Despite definitive treatment, there is a high rate of recurrence, most commonly in the bone, lung or liver. Brain metastases and particularly, leptomeningeal carcinomatosis are extremely rare. We present a case of recurrent nasopharyngeal carcinoma with brain metastases and leptomeningeal carcinomatosis in the absence of local recurre...

Honokiol may exert significant antineoplastic effects in other systemic tumors besides skin cancers by virtue of modulation of other pathways. For instance, honokiol attenuates tumor growth in mammary malignancies. It mediates its anti-neoplastic role in these tumors by accentuating the phosphorylation of AMPK. As a result, honokiol causes significant mitigation of tumor proliferation and growth.

Cancers prime neutrophils to release extracellular DNA traps through the systemic release of granulocyte colony-stimulating factor (G-CSF). We recently showed that these circulating neutrophil extracellular traps (NETs) promote the establishment of a pro-thrombotic state. The role of NETs in cancer biology and tumor progression may prove much more than an unfortunate side effect of cancer.

Radiotherapy can convert malignant cells into an in situ anticancer vaccine, but is often inadequate at generating sufficient pro-inflammatory signals to optimally activate innate and adaptive immune responses. Topical imiquimod is a powerful pro-inflammatory agent with clinical activity against superficial skin cancers. These two modalities appear to complement each other, hence achieving loca...

Conventional beliefs and some publications, had in the past, asserted that systemic auto immune diseases such as inflammatory arthritis, connective tissue diseases and vasculitis are rare. Many of such reports had been hospital based and were not based on the ACR criteria. Rheumatoid arthritis was reported as being rare, especially among West Africans; so also Systemic Lupus Erythematosus, Scle...

We report two cases of liver metastases from colorectal and anal cancers after the failure systemic chemotherapies that were successfully treated with a combination therapy transarterial chemoembolization using irinotecan-loaded drug-eluting beads hepatic arterial infusion chemotherapy. In both cases, chemotherapy was performed as maintenance beads. Irinotecan at dose 120 mg loaded on drug deli...