INTRODUCTION .......................................................................................................................................................229 Clinical Leishmaniasis ...........................................................................................................................................229 Self-limiting cutaneous and visceral leishmaniasis ...............

INTRODUCTION .......................................................................................................................................................229 Clinical Leishmaniasis ...........................................................................................................................................229 Self-limiting cutaneous and visceral leishmaniasis ...............

OBJECTIVE To determine the Crimean Congo Hemorrhagic Fever (CCHF) virus M segement glycoprotein's immunoinformatic parameters, and identify Human Leukocyte Antigen (HLA) class I binders as candidates for synthetic peptide vaccines. STUDY DESIGN Cross-sectional study. PLACE AND DURATION OF STUDY Combined Military Hospital, Khuzdar Cantt, in May 2015. METHODOLOGY Data acquisition, antigenic...

Human antibodies generated by Epstein-Barr virus immortalized B-cells from tumor-draining lymph nodes of an ovarian cancer patient were screened for reactivity in enzyme-linked immunosorbent assay with a synthetic peptide corresponding to the protein core of the polymorphic epithelial mucin. Epitopes within this region are in fact considered tumor specific since they are selectively exposed in ...

There are many challenges in the field of public health sciences. Rational decisions are required in order to treat different diseases, gain knowledge and wealth regarding research, and produce biological or synthetic products. Various advances in the basic laboratory science, computer science, and the engineering of biological production processes can help solve the occurring problems. Bioinfo...

These are exciting times in the development of new immunotherapeutic strategies for cancer therapy. In particular, synthetic peptide-based vaccines, aiming at the induction of T-cell mediated anti-tumor immunity, hold immense promise for prevention and therapy of malignant diseases. Synthetic peptides are easily produced, are chemically stable, easily deliverable, free of infectious contaminant...

The M protein is the primary vaccine candidate to prevent group A streptococcal (GAS) infection and the subsequent development of rheumatic fever (RF). However, the large number of serotypes have made it difficult to design a vaccine against all strains. We have taken an approach of identifying amino-terminal M protein epitopes from GAS isolates that are highly prevalent in GAS-endemic populati...

Introduction: Subunit vaccines represent an important aspect of modern vaccination. In this respect, the possibility to construct peptide-based vaccines is particularly appealing and peptides that e.g. mimic epitopes of pathogens, can be designed to induce well-defined monofunctional immune responses. Multi-epitopic constructs that contain epitopes from the same and/or different pathogen(s) can...

The interferon gamma, enzyme-linked immunospot (IFN-γ ELISpot) assay is widely used to identify viral antigen-specific T cells is frequently employed to quantify T cell responses in HIV vaccine studies. It can be used to define T cell epitope specificities using panels of peptide antigens, but with sample and cost constraints there is a critical need to improve the efficiency of epitope mapping...