Neurosteroids are steroids that are produced in the central nervous system (CNS). While progesterone and dehydroepiandostendione (the precursors of testosterone) are among the identified neurosteroids, it is not clear that testosterone could be considered as a neurosteroid. The testosterone synthesis has been demonstrated in the brain of castrated frog, but not in the rat brain. In the present ...

The synthesis of the first mesogenic donor-acceptor polyoxometalate (POM)-based hybrid is herein described. structural and electronic properties compound were evaluated through combination small- wide-angle X-ray scattering, optical microscopy, electrochemistry photoluminescence. In solid state, behaves as a birefringent solid, displaying lamellar organization in which double-layers POMs bis(th...

In recent years, several radiopharmaceuticals have been developed for imaging regional cerebral blood flow (rCBF) such as 75Se labelled PIPSE and MOSE, ²º¹TI labelled DDC and 99mTc labelled HMPAO. HMPAO with two asymmetric carbon atoms (At the 3 and 9 positions), produces d,1 and meso isomers, only one of which is retained in the brain. Rapid intracellular conversion of 99mTc-d,1-HMPAO to...

This study reports the simple process to synthesis of CuO/CuI nanocomposite in a non-aqueous solution. In the conducted experiments CuI and Dimethyl Sulfoxide (DMSO) were used as the precursors. Moreover, DMSO had role of solvent and ligand simultaneously. In experiments the effects of oleic acid as the particles size modifier, temperature and concentration were investigated. Crystalline struct...

The biosynthetic origins of the isocyanide and isothiocyanate functional groups in the marine sponge metabolites diisocyanoadociane (1), 9-isocyanopupukeanane (10) and 9-isothiocyanatopupukeanane (11) are probed by the use of [(14)C]-labelled precursor experiments. Incubation of the sponge Amphimedon terpenensis with [(14)C]-labelled thiocyanate resulted in radioactive diisocyanoadociane (1) in...

Sequence homologies suggest that the Bacillus subtilis 168 tagO gene encodes UDP-N-acetylglucosamine:undecaprenyl-P N-acetylglucosaminyl 1-P transferase, the enzyme responsible for catalysing the first step in the synthesis of the teichoic acid linkage unit, i.e. the formation of undecaprenyl-PP-N-acetylglucosamine. Inhibition of tagO expression mediated by an IPTG-inducible P(spac) promoter le...