On in vitro incubation of articular and epiphysial cartilage of the ulna of the domestic pig 70 to 80 per cent of [U-14C] glucose was metabolised to 14C-lactate, but cartilage of the epiphysial plate produced up to five times as much 14C-CO2 as articular cartilage, and the specific radioactivity of 14C(or 35S)-chondroitin 4(6)-sulphate isolated from epiphysial cartilage (following 35S-sulphate ...

In this series of papers the first (Blair, 1963) described synthetic diets for young pigs, and the second (Blair, Diack & McPherson, 1963) described the pattern of development of the limb bones of suckled pigs during the first 8 weeks of life. The aim of the study now described was to determine what dietary levels of calcium and phosphorus, with or without the addition of fresh ox liver, would ...

We report a case of a 21-year old male with an asymptomatic solitary costal exostosis incidentally detected on a chest X-ray. The exostosis originated from the costochondral junction of the left fourth rib and protruded into the thoracic cavity. Exploratory thoracoscopy showed that the exostosis had scratched the adjacent pericardium and visceral pleura. A 5.5-cm long rib segment including the ...

tion of the heart, and particularly of the right ventricle, when the heart is in its correct central position. If during intra-uterine life the heart is not central and during development lies to the left side, leaving the mediastinum empty, there will be no positive force to elevate the sternum, but rather a negative pressure which will suck it in. The ribs and sternum ossify early, but the co...

Chondrocytes isolated from the epiphysial cartilage of chickens were exposed to either the ionophore A23187 or KCN, in the presence of 0.4 mM-extracellular Ca2+. This treatment elicits a prompt release of cell Ca2+, which can be measured as net cation efflux by a highly sensitive Ca2+-selective electrode system. Pre-exposure of chondrocytes to the metabolic inhibitors 2-deoxy-D-glucose or oligo...

Achondroplasia (ACH) and thanatophoric dysplasia (TD) are caused by gain-of-function mutations of fibroblast growth factor receptor 3 (FGFR3) and they are the most common forms of dwarfism and lethal dwarfism, respectively. Currently, there are few effective treatments for ACH. For the neonatal lethality of TD patients, no practical effective therapies are available. We here showed that systemi...

PURPOSE We review published research on temporomandibular joint (TMJ) total replacement that compares costochondral graft and customized total joint reconstruction (especially TMJ concepts), focusing on effectiveness. METHODS We searched PubMed databases, including prospective, retrospective, case-control or longitudinal studies and significant statistical analysis. In data analysis, we divid...

(1) That the apex of the lung extends about one and a half inches above the middle third of the clavicle and hence may be involved in a wound of the neck, producing all the complications of a chest wound such as emphysema, pneumothorax and hajmothoraX(2) That the lower border of the lungs lies about two fingers' breadth above the pleural reflection(3) That the main fissure of each lung is repre...

Phrenic nerve stimulation, electrical (ES) or from cervical magnetic stimulation (CMS), allows one to assess the diaphragm contractile properties and the conduction time of the phrenic nerve (PNCT) through recording of an electromyographic response, traditionally by using surface electrodes. Because of the coactivation of extradiaphragmatic muscles, signal contamination can jeopardize the deter...

A fundamental orthopaedic problem to-day is the understanding of the fate of bone transplants. Since homogenous preserved bone is increasingly used, this study investigated the survival of the calcifying mechanism under storage conditions typically employed in preserving homogenous bone for orthopaedic use. It was our hope that the method might be used to indicate the relative value of the vari...