The suitability of individual MAb for application in vivo should be carefully confirmed. The monoclonal antibody GL-013, with specific binding reactivity in vitro to human tumors of the gastrointestinal tract, was radioiodinated and injected intraperitoneally into nude mice bearing human gastric carcinoma xenografts SY 86 B (moderately differentiated glandular adenocarcinoma) and SY 86 D (signe...

Surgical resection coupled with adjuvant radiotherapy and/or doxorubicin based chemotherapy are the mainstays of synovial sarcoma (SS) treatment. Although effective as a SS adjuvant, the proposed mechanism of action of doxorubicin remains controversial. Current opinion supports DNA damage-induced apoptosis. This in vitro study used cDNA gene expression profiling to investigate whether apoptosis...

We consider the infrared quasi fixed point solutions of the renormalization group equations for the Yukawa couplings and soft supersymmetry breaking parameters in the MSSM in the large tan β regime. The existence of IR quasi fixed points together with the values of gauge couplings, third generation quarks, lepton and Z-boson masses allows one to predict masses of the Higgs bosons and SUSY parti...

Synovial sarcoma (SS) is a highly aggressive, periarticular soft tissue sarcoma that causes death in more than half of affected children, adolescents, and young adults. Five- and 10-year survival rates are as low as 36 and 20%, respectively. Bcl-2, a negative regulator of apoptosis, is overexpressed in up to 90% of SS. Increased Bcl-2 expression not only leads to the development of cancer, but ...

Human Creutzfeldt-Jakob disease (CJD) and similar neurodegenerative diseases such as sheep scrapie are caused by a variety of related infectious agents. They are associated with abnormal host prion protein (PrP), which is assessed by limited proteolysis to yield resistant PrP bands (PrP-res). Although PrP-res has been posited as the infectious agent, purified PrP-res itself is not infectious. T...

Reeds sedert haar studentedae het Ilse Feinauer onderskei as iemand met ’n besondere en veelsydige gerigtheid op bekwaamheid in die breër terrein van (Afrikaanse) taalwetenskap. Sy was gelukkige posisie om gevorderde nagraadse werk onder studieleiding bekwame studieleiers mentors te kon voltooi – Johan Combrink studieleier MA-tesis (oor taalkundige gedrag vloekwoorde Afrikaans) Fritz Ponelis pr...

A regional regression model was developed to estimate the spatial distribution of ground water recharge in subhumid regions. The regional regression recharge (RRR) model was based on a regression of basin-wide estimates of recharge from surface water drainage basins, precipitation, growing degree days (GDD), and average basin specific yield (SY). Decadal average recharge, precipitation, and GDD...

Three common food colorants (tartrazine TT, allura red AR, and sunset yellow SY) were simultaneously quantified in powdered soft drinks by employing a combination of absorbance spectra-pH data matrices and multivariate processing of the generated second-order data. Parallel factor analysis PARAFAC and bilinear least squares/residual bilinearization BLLS/RBL were applied for deconvolution of tri...

BACKGROUND Using a rat model we have found that the bioflavonoid silymarin (SY) ameliorates some of the negative consequences of in utero exposure to ethanol (EtOH). In the current study our aim was to determine if spatial working memory (SWM) was impaired in offspring whose mothers were maintained on a liquid diet containing EtOH during different gestational weeks. We also determined if SWM wa...