The aim of the present study was to develop a sustained release monolithic system for the low solubile/low dose glipizide, for the treatment of type II diabetes mellitus. The matrices were prepared by dry blending of polymers hydroxy propyl methyl cellulose (HPMC) or erodible Eudragit (ammonio methacrylate copolymers) and other excipients using direct compression method and were characterized u...

the present study concerned with the development and characterization of metronidazole microcapsules prepared by thermal change method using different ratios (1:1, 1:2 and 1:4) of ethyl cellulose in order to select the best microcapsule formulation with a good encapsulation efficiency and drug release profile. the obtained microcapsules were discrete, spherical with free flowing properties and ...

Interpenetrating polymer network hydrogel beads of pectin and sodium carboxymethyl xanthan were prepared by ionotropic gelation with Al(+3) ions and covalent cross-linking with glutaraldehyde for sustained delivery of diltiazem hydrochloride. Fourier transform infrared spectroscopy, X-ray diffraction, differential scanning colorimetry and scanning electron microscopy were used to characterise t...

Migraine, a neurological condition is often associated with intense, throbbing, crippling headaches for hours to days. Rizatriptan benzoate has established its potential in controlling the symptoms of migraine. The present study aims formulate bilayer tablet rizatriptan multi release unit matrix embedded sustained layer achieve pulsatile drug control various phases A preliminary on four matrice...

Abstract Injectable hydrogels derived from natural extracellular matrices exhibit excellent adhesion to endothelial cells in vitro and are ideal for many biomedical applications. However, their applicability vivo is limited by the risk of infection or immunogenicity, current injectables also suffer degradation, viscosity, drug release. In this study, a multifunctional hydrogel scaffold (COB hyd...

The aim of the current study was to design sustained release matrix tablets of venlafaxine hydrochloride using ion exchange resin with the incorporation of hydrophilic and hydrophobic polymer combinations. Venlafaxine HCl was loaded onto Indion 244 by batch method and then resinate were wet granulated with ethyl cellulose and blended with hydroxypropylmethylcellulose and compressed. A central c...