Calcium phosphate ceramics are widely used as bone substitutes in dentistry and orthopedic applications. For minimally invasive surgery an injectable calcium phosphate ceramic suspension (ICPCS) was developed. It consists in a biopolymer (hydroxypropylmethylcellulose: HPMC) as matrix and bioactive calcium phosphate ceramics (biphasic calcium phosphate: BCP) as fillers. The stability of the susp...

Surgical treatment of thumb basal joint arthritis is aimed at pain relief, restoration of pinch strength, and stability. We describe a variation of the abductor pollicus longus (APL) suspension arthroplasty originally described by Thompson, which maximizes strength of repair and is technically simple to perform. The technique consists of a trapeziectomy followed by resection of a slip of the AP...

This paper proposes a novel method for designing robust nonlinear multivariable predictive control for nonlinear active suspension systems via the Takagi-Sugeno fuzzy approach. The controller design is converted to a convex optimization problem with linear matrix inequality constraints. The stability of the control system is achieved by the use of terminal constraints, in particular the Constra...

A wing-payload system is a two-body flight vehicle with a payload suspended below the wing through a large number of suspension lines. The present study gives a detailed description of 4-DOF longitudinal flight dynamic model of the wing-payload system. The aerodynamic coefficients of the wing are generated using CFD simulations whereas those of the payload are estimated from empirical relations...

An LC-MS/MS method was developed and validated to be used as a stability indicating assay for the study of a 3 mg/mL lansoprazole oral suspension. The method utilizes a UPLC (ultra-performance liquid chromatography) column and unique mass spectrometric detection (ion-trap time-of-flight (IT-TOF)) to achieve a sensitive (LOD 2 ng/mL), accurate, and reproducible quantification of lansoprazole. Th...

The oral route of drug administration is generally preferred because of its versatility, safety and relative patient comfort. Liposomes have received much attention for their usefulness in reducing toxicity and improving therapeutic effectiveness. Although liposomes are a most promising, broadly applicable, and highly researched novel delivery system, they suffer from serious stability problems...

in suspension polymerization, particle size distribution of polymer is the outcome of dynamic equilibrium between the break up and coalescence phenomena. the rates of break up and coalescence and consequently polymerization stability depend on several parameters, the most important of which are type and concentration of stabilizer. in this study, the effects of type and concentration of stabili...

For some linear mechanical systems, which can be written as a dyadic transfer function matrix (DTM), MIMO controller design can be reduced to a number of SISO designs. Internal stability of the SISO designs guarantees stability of the resulting MIMO controller. By relating the insights from modal analysis to system theory, necessary and sufficient conditions are derived for linear mechanical sy...

This paper presents an implementation of stable direct adaptive control on nonlinear systems using lyapunov function with fuzzy approach. Stable direct adaptive control law consists of an ideal control, and a sliding mode control. Sliding mode controller is used to ensure the stability of Lyapunov function. Stability of direct adaptive control law is tested on two nonlinear systems. Non linear ...

BACKGROUND Torsemide use for congestive heart failure (CHF) has been reported, but prescription frequency is unknown. Commercially available tablet sizes in North America limit dosing precision, indicating a need to evaluate its strength and stability in suspension. OBJECTIVES To determine the frequency of torsemide prescriptions and to determine a beyond use date (BUD) of a compounded suspen...