Emelie Holmquist Ms ([email protected]) Bart Reitsma Mr ([email protected]) Ben C King Dr ([email protected]) Astrid Escudero-Esparza Dr ([email protected]) Sioned Owen Dr ([email protected]) Akira Orimo Dr ([email protected]) Marcin Okroj Dr ([email protected]) Lola Anagnostaki Dr ([email protected]) Wen G Jiang prof ([email protected]) Ka...

The etiologic agent of Lyme disease, Borrelia burgdorferi, is capable of circumventing the immune defense of a variety of potential vertebrate hosts. Previous work has shown that interaction of host-derived complement regulators, factor H and factor H-like protein 1 (FHL-1), with up to five complement regulator-acquiring surface proteins (CRASPs) expressed by resistant B. burgdorferi sensu lato...

We present a model for aggregation of product review snippets by joint aspect identification and sentiment analysis. Our model simultaneously identifies an underlying set of ratable aspects presented in the reviews of a product (e.g., sushi and miso for a Japanese restaurant) and determines the corresponding sentiment of each aspect. This approach directly enables discovery of highly-rated or i...

Supplementary data ml http://rsbl.royalsocietypublishing.org/content/suppl/2010/04/13/rsbl.2010.0156.DC1.ht "Data Supplement" References #ref-list-1 http://rsbl.royalsocietypublishing.org/content/early/2010/04/13/rsbl.2010.0156.full.html This article cites 16 articles, 1 of which can be accessed free P<P Published online 21 April 2010 in advance of the print journal. This article is free to acc...

Plant nucleotide-binding leucine-rich repeat (NB-LRR) disease resistance (R) proteins recognize specific "avirulent" pathogen effectors and activate immune responses. NB-LRR proteins structurally and functionally resemble mammalian Nod-like receptors (NLRs). How NB-LRR and NLR proteins activate defense is poorly understood. The divergently transcribed Arabidopsis R genes, RPS4 (resistance to Ps...

BACKGROUND Two healthcare innovations were successfully implemented using different implementation strategies. First, a Short Stay Programme for breast cancer surgery (MaDO) was implemented in four early adopter hospitals, using a hospital-tailored implementation strategy. Second, the Enhanced Recovery After Surgery (ERAS) programme for colonic surgery was implemented in 33 Dutch hospitals, usi...

BACKGROUND The use of DNA barcodes for the identification of described species is one of the least controversial and most promising applications of barcoding. There is no consensus, however, as to what constitutes an appropriate identification standard and most barcoding efforts simply attempt to pair a query sequence with reference sequences and deem identification successful if it falls withi...

Abnormal regulation of the complement alternative pathway is associated with C3 glomerulopathy. Complement factor H is the main plasma regulator of the alternative pathway and consists of 20 short consensus repeat (SCR) domains. Although recombinant full-length factor H represents a logical treatment for C3 glomerulopathy, its production has proved challenging. We and others have designed recom...