A 2 years and 9 months old boy attended to a gastroenterology clinic of pediatric hospital for investigation of recurrent and intractable vomiting. He had post prandial, non-projectile, non-bilious emesis since past 2 years. Since the onset of illness, he was carried to many doctors and underwent extensive laboratory investigations. Because all of the science lab and imaging work up for etiolog...

QUESTION Question: How effective are behavioural therapies for depression? METHODS Design: Systematic review with meta-analysis. Index were searched from inception to January 2006 for randomised controlled trials (RCTs). Reference lists of identified studies were hand searched. Study selection and analysis: Two reviewers appraised studies and selected RCTs of behavioural therapy in adults (aged...

BACKGROUND Crohn's disease (CD) is associated with depression. It is unclear if psychosocial interventions offer benefit for depressive symptoms during active CD. In this secondary analysis of a larger study of treating depression in pediatric inflammatory bowel disease, we assessed whether cognitive behavioral therapy (CBT) would differentiate from supportive nondirective therapy in treating d...

BACKGROUND Deficits in social cognition and neurocognition are believed to underlie schizophrenia disability. Attempts at rehabilitation have had circumscribed effects on cognition, without concurrent improvement in broad aspects of behavior and adjustment. OBJECTIVE To determine the differential effects of cognitive enhancement therapy (a recovery-phase intervention) on cognition and behavio...

The effects of psychotherapies for depression have been examined in several hundreds randomized trials, but no recent network meta-analysis (NMA) has integrated the results these studies. We conducted an NMA trials comparing cognitive behavioural, interpersonal, psychodynamic, problem-solving, behavioural activation, life-review and “third wave” therapies non-directive supportive counseling wit...

BACKGROUND Meaning-focused coping may be at the core of adequate adjustment to life after cancer. Cancer survivors who experience their life as meaningful are better adjusted, have better quality of life and psychological functioning. Meaning-Centered Group Psychotherapy for Cancer Survivors (MCGP-CS) was designed to help patients to sustain or enhance a sense of meaning and purpose in their li...

OBJECTIVE This study tested whether the quality of the patient-rated working alliance, measured early in treatment, predicted subsequent symptom reduction in chronically depressed patients. Secondarily, the study assessed whether the relationship between early alliance and response to treatment differed between patients receiving cognitive behavioral analysis system of psychotherapy (CBASP) vs....

BACKGROUND Bonafide psychotherapy is an effective treatment for generalised anxiety disorder compared to no-treatment. Rather than creating increasing numbers of new overall treatment-packets within a medical meta-model, an additional approach to investigating clinical research designs may be to increase the understanding of already effective psychotherapies. Treatment manuals and protocols all...

The number needed to treat (NNT) statistic was developed to facilitate the practice of evidence-based medicine. Placebo was assumed to be therapeutically inert when the NNT was originally conceived, but more recent data for conditions such as major depressive disorder (MDD) suggest that the placebo control condition can have considerable therapeutic effects. Complications arise because the NNT ...