Case 1 An elderly patient presented with insidious onset of sensorineural hearing loss. The past history was unremarkable except for insidious onset of weakness of left lower limb. Physical examination revealed left hemiparesis with upgoing left plantar. Magnetic resonance imaging (MRI) of brain revealed a large flow void in the interpeduncular cistern suggestive of aneurysm arising from the to...

BACKGROUND The future of personalized medicine depends on advanced diagnostic tools to characterize responders and non-responders to treatment. Systems diagnosis is a new approach which aims to capture a large amount of symptom information from patients to characterize relevant sub-groups. METHODOLOGY 49 patients with a rheumatic disease were characterized using a systems diagnosis questionna...

Recordings were made from small and medium diameter dorsal root ganglia (DRG) neurons that expressed transient receptor potential (TRP) proteins. Physiologically characterized skin nociceptors expressed either TRPV1 (type 2) or TRPV2 (type 4) in isolation. Other nociceptors co-expressed both TRP proteins and innervated deep tissue sites (gastrocnemius muscle, distal colon; type 5, type 8) and s...

How hot is the human body? HOW MUCH BODY HEAT is gained or lost during exercise and/or environmental exposure? This seems like a simple question that should be easily quantified; however, this is an unresolved issue that likely has produced flawed deductions concerning thermoregulatory control and treatment affects on body heat content (3, 8, 13, 15). Body heat content is the product of mean bo...

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Dynamic psychology is based on a concept of mind that is opposed to mechanism and the cause/effect relationship; indeed, it is essentially phenomenological and is founded on a system of principles articulated according to the mind/body itinerary. As such, dynamic psychology is based on the dynamics of the unconscious, the principle of field in terms of conflict and communication, the superficia...