Inflammation contributes to the development of papillomas and squamous cell carcinomas in the well-established 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-l3-acetate (TPA) model of skin carcinogenesis. Synthetic oligonucleotides (ODN) containing repetitive TTAGGG motifs have been shown to block deleterious inflammatory reactions in murine models of autoimmunity, pneumonitis,...

We are studying five interacting genes involved in the regulation or coordination of muscle contraction in Caenorhabditis elegans. A distinctive "rubber-band" muscle-defective phenotype was previously shown to result from rare altered-function mutations in either of two of these genes, unc-93 and sup-10. null mutations in sup-9, sup-10, sup-18 or unc-93 act as essentially recessive suppressors ...

Choline availability in the maternal diet has a lasting effect on brain and behavior of the offspring. To further delineate the impact of early nutritional status, we examined effects of prenatal-choline supplementation on timing, emotion, and memory performance of adult male and female rats. Rats that were given sufficient choline (CON: 1.1 g/kg) or supplemental choline (SUP: 5.0 g/kg) during ...

A large reservoir of bacterial lipopolysaccharide (LPS) is available in the colon and this could promote colon cancer metastasis by enhancing tumor cell adhesion, intravasation, and extravasation. Furthermore, adhesion molecules like ICAM-1, VCAM-1, and E-selectin play important roles in the adhesion of tumor cells to endothelium. This study was designed to determine whether morphine can attenu...

Identifying explosive bubbles under the influence of their periodically collapsing property has long been a concern in bubble testing literature. In this paper, we argue that the sup Augmented Dickey-Fuller (ADF) test (Phillips, Wu and Yu, 2009), which implements a right-tail ADF test and a sup test on a forward expanding sample sequence, is sensitive to the sample starting point when there are...

AIM Multi-profile monitoring of various blood serum factors during acute subarachnoid haemorrhage (SAH) is crucial for successful treatment. The aim of the study is to evaluate the serum concentration of different blood factors in the acute period of SAH. MATERIAL AND METHODS 31 patients with confirmed aneurysmal SAH were enrolled in a prospective study. The concentrations of the following se...

For a polynomial p of degree n<N we compare two norms: ‖p‖ := sup{|p(z)| : z ∈ C; |z| = 1} and ‖p‖N := sup {∣∣p (zj )∣∣ : j = 0, . . . , N − 1} ; zj = e2 i j N . We show that there exist universal constants C1 and C2 such that 1+ C1 log ( N N − n ) sup { ‖p‖ ‖p‖N : p ∈ Pn } C2 log ( N N − n ) + 1. © 2005 Elsevier Inc. All rights reserved.

Development of the Caenorhabditis elegans foregut (pharynx) is regulated by a network of proteins that includes the Retinoblastoma protein (pRb) ortholog LIN-35, the ubiquitin pathway components UBC-18 and ARI-1, and by PHA-1, a cytoplasmic protein. Loss of pha-1 activity impairs pharyngeal development and body morphogenesis, leading to embryonic arrest. We have used a genetic suppressor approa...