نتایج جستجو برای: sumo1
تعداد نتایج: 347 فیلتر نتایج به سال:
The production of mature sperm is reliant on androgen action within the testis, and it is well established that androgens act on receptors within the somatic Sertoli cells to stimulate male germ cell development. Mice lacking Sertoli cell androgen receptors (AR) show late meiotic germ cell arrest, suggesting Sertoli cells transduce the androgenic stimulus co-ordinating this essential step in sp...
Multiple components of the SUMOylation machinery are deregulated in various cancers and could represent potential therapeutic targets. Understanding role tumor progression aggressiveness would increase our insight SUMO cancer clarify its as a target. Here we investigate relation to conventional chondrosarcomas, which malignant cartilage forming tumors bone. Aggressiveness chondrosarcoma increas...
Here, we demonstrate that SENP2, a desumoylating enzyme, plays a critical role in the control of adipogenesis. SENP2 expression was markedly increased upon the induction of adipocyte differentiation, and this increase was dependent on protein kinase A activation. Remarkably, knockdown of SENP2 led to a dramatic attenuation of adipogenesis with a marked decrease in PPARgamma and C/EBPalpha mRNA ...
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