Aromatic sulfones comprise a class of chemicals used in agrochemical and pharmaceutical industries and as floatation and extractant agents in petrochemical and metallurgy industries. In this study, new QSA(P)R studies were carried out to predict the toxicity against Vibrio fischeri of a set of 52 aromatic sulfones. The same approach was used to evaluate the relationship between these endpoint a...

Sulfonamide- and sulfone-induced hypersensitivity reactions are thought to be mediated through bioactivation of parent drug molecule(s) to their respective reactive metabolite(s). Recent studies have demonstrated that keratinocytes can bioactivate sulfonamides and sulfones. Using enzyme-linked immunosorbent assay and hapten-specific rabbit antisera developed in our laboratory, we found that inc...

Almost to be expected, as the concomitant of a new chemotherapeutic agent, is the development of drug resistance by formerly sensitive organisms. Sometimes this is such a frequen t occurrence that the drug ceases to be useful ; with other drugs the appearance of resistant strains is a rarity. Throughout the twenty year experience with sulfones in leprosy, the incidence of resistance has appeare...

INTRODUCTION .......................................................................................................................................................161 MECHANISM OF ACTION OF -LACTAM ANTIBIOTICS .............................................................................161 RESISTANCE TO -LACTAM ANTIBIOTICS ..........................................................................

The major sex pheromone components of Drosophila ananassae and D. pallidosa, (Z,Z)-5,25-hentriacontadiene and (Z,Z)-5,27-tritriacontadiene, respectively, were synthesized by using the Wittig olefination and sulfone coupling reactions as the C-C bond-forming steps.

The exploration of inexpensive and stable heterogeneous catalysts for C–S coupling reactions remains a challenging issue. Herein, we successfully prepared new biomass-derived copper catalyst applied it to the selective C(sp3)–H-directed sulfonylation ketone hydrazones with commercial sodium sulfinates. was characterized using different spectroscopic microscopic techniques. Importantly, biomass-...

A series of N-(2,4-difluorophenyl)-N’-heptyl-N’4-[(substituted)-pyridazin-3yl)thio]pentyl urea derivatives having a phenyl ring at positions 5 and/or at position 6 of the heterocycle, as well as the corresponding sulfones, were synthesized. Their inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) was tested on the enzyme prepared from rat liver microsomes. Theoretical studi...