An innovative and versatile strategy of Solid Phase Microextraction (SPME) is shown by using a new type of β-cyclodextrin-modified nanocellulose (CD-NC) as a sorbent material. β-cyclodextrin (used as an inclusion-type selector) was covalently bonded to amine-modified nanocellulose by an amidation reaction. Such novel nanocavities were successfully applied to the selective recognition of danoflo...

In this study, the encapsulation mechanism of oxyresveratrol and β-cyclodextrin (β-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD) was studied. As this research shows, oxyresveratrol and two cyclodextrins (CDs) were able to form inclusion complexes in a 1:1 stoichiometry. However, the interaction with HP-β-CD was more efficient, showing up as higher encapsulation constant (KF) (35,864.72 ± 3415....

The formation and structure of inclusion complexes of αand β-cyclodextrins with 2-chlorophenol (2CP), 3-chlorophenol (3CP), 4-chlorophenol (4CP), 2,4-dichlorophenol (24DCP), 2,6-dichlorophenol (26DCP) and 3,4-dichlorophenol (34DCP) have been studied by UV-VIS and 1H NMR spectroscopy. Both cyclodextrins were found to form 1 : 1 inclusion complexes. Binding constants estimated from titration stud...

The inclusion complexes of cyclodextrins (CDs) with flavones in aqueous solution were investigated by phase solubility measurements. The effect of β-cyclodextrin (β-CD), heptakis (2,6-di-O-methyl) β-cyclodextrin (DM-β-CD) and 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) on the aqueous solubility of three flavones, namely, chrysin, apigenin and luteolin was investigated, respectively. Solubility enh...

Chiral separations of 1-aminoindan (AI) by cyclodextrin electrokinetic chromatography (CDEKC) were investigated on microfluidic quartz chips. By using a microchip electrophoresis (MCE) instrument equipped with a linear-imaging UV detector, the separation process of the enantiomeric compounds was observed. When sulfated beta-cyclodextrin was employed as a chiral selector, the baseline separation...

A one-pot method for the preparation of benzoyl metronidazole was achieved by using N,N'-carbonyldiimidazole as a coupling reagent. Moreover, it was found that the byproduct imidazole as the catalyst promoted the reaction. In addition, the β-cyclodextrin solubilization of benzoyl metronidazole was investigated by phase-solubility method. The phase-solubility studies indicated that the solubilit...

Cyclodextrins are a group of novel excipients, extensively used in the present pharmaceutical industry. Sometimes they show significant interactions with other conventional additives used in the formulation of dosage forms. The effect of β-cyclodextrin on the rheological properties of aqueous solutions of some selected viscosity modifiers was studied in the present work. β-cyclodextrin showed t...

Eosin B (EoB) and eosin Y (EoY), two xanthene dye derivatives with photosensitizing ability were prepared in high purity through an improved synthetic route. The dyes were grafted to a 6-monoamino-β-cyclodextrin scaffold under mild reaction conditions through a stable amide linkage using the coupling agent 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride. The molecular conjuga...

The reaction of β-cyclodextrin with suitable bifunctional cross-linkers (such as carboxylic acids dianhydrides) provides 3D nanoporous polymers referred to cyclodextrin nanosponges (CDNS). swelling ability many CDNS can be exploited confine small active molecules, such drugs, in the resulting hydrogel, thus providing drug-loaded hydrogels. This raises an increasing interest toward hydrogels bio...