Neurocysticercosis (NCC), a helminth infection of the brain, is a major cause of seizures. The mediators responsible for seizures in NCC are unknown, and their management remains controversial. Substance P (SP) is a neuropeptide produced by neurons, endothelial cells and immunocytes. The current studies examined the hypothesis that SP mediates seizures in NCC. We demonstrated by immunostaining ...

Highly purified human serum cholinesterase (EC 3.1.1.8, also known as pseudocholinesterase and butyrylcholinesterase) had peptidase activity toward substance P. Digestion of substance P was monitored by high performance liquid chromatography, which separated three product peptides. The cleavages occurred sequentially. The first peptide to appear as Arg1-Pro2. The Km for this hydrolysis was 0.3 ...

involution of the pituitary tumor, the chiasm itself may herniate into an enlarged and relatively empty sella. In some cases, this may result in traction and kinking of axons with renewed loss of function. Likewise, although the intracranial pressure diminishes following cerebrospinal fluid leaks, deterioration of visual function can also be expected when the brain, no longer buoyed by fluid, s...

Light-microscopic immunocytochemistry was utilized to localize the different populations of substance P-immunoreactive (SP-IR) neurons in the hamster retina. Based on observation of 2505 SP-IR neurons in transverse sections, 34% were amacrine cells whose pear-shaped or round cell bodies (7-8 microm) were situated in the inner half of the inner nuclear layer (INL) or in the inner plexiform layer...

1 Extraction, Biological Testing and Structural Elucidation . . . . . . . . . . . . 1 2 Masanori Otsuka and the Action of Substance P in the Spinal Cord . . . . . . 8 3 Radioimmunoassay and Immunohistochemistry of Substance P . . . . . . . . 8 4 Nicolas Jancs and Capsaicin . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 5 Peptide and Nonpeptide Transmitters in Primary Afferent Neuron...

Background: Substance P (SP) is a neuropeptide that functions as a neuromodulator. It is released mainly in the brain stem and in nerve endings. Aims: The present study aimed to provide fundamental data that may be applied to the assessment of pain in dogs by evaluating their serum SP concentrations. Methods: Two groups of dogs were designated ...

Recent evidence has suggested that neuropeptides, and in particular substance P (SP), may play a critical role in the development of morphological injury and functional deficits following acute insults to the brain. Few studies, however, have examined the role of SP, and more generally, neurogenic inflammation, in the pathophysiology of traumatic brain injury and stroke. Those studies that have...