Vogt-Koyanagi-Harada disease is a chronic, granulomatous systemic autoimmune disease with manifestations in the ocular, central nervous, auditory, and integumentary systems. The target of attack seems to be antigens associated with melanocytes. Patients are usually of Asian, Middle Eastern, Asian Indian, Native American, or Hispanic ethnicity, and complain of neurologic symptoms quickly followe...

The hallmark feature of the wet or neovascular form of age-related macular degeneration is the presence of choroidal (or retinal) neovascularization (CNV). If left untreated, CNV may result in significant central vision loss due to complications including exudation, leakage, and ultimately subretinal fibrosis causing remarkable photoreceptor loss. Although the mechanism of development is not fu...

background: uveitis refers to diseases characterized by intraocular inflammation of the uveal tract. anterior uveitis is a common ocular disease characterized by inflammation of the iris and the ciliary body. objectives: to establish the frequency of hla-b27- positive uveitis in asian indian population, study their clinical profile and compare it with other reports in literature. methods: we re...

Granuloma annulare is self-limiting cutaneous condition of unknown etiology, causing necrobiotic dermal and subcutaneous papules. A number of conditions have been described in association with Granuloma annulare, including lymphoma, anemia, intestinal bleeding, seronegative arthralgia, vasculitis and autoimmune thyroiditis. This manuscript, as the first report of this combination in Iran, descr...

BACKGROUND The impact of intestinal helminth infection on the clinical presentation and immune response during active tuberculosis (TB) infection is not well characterized. Our aim was to investigate whether asymptomatic intestinal helminth infection alters the clinical signs and symptoms as well as the cell mediated immune responses in patients with active TB. METHODOLOGY Consecutive, newly ...

Solar radio bursts have been associated with a number of disruptions in avionic systems. The objective this work is to develop solar burst interference thresholds which account for the technical specifications aviation-related instrumentation, instrument operating frequencies as well industry stipulated error tolerances. are suggested be potentially hazardous when exceeding these calculated thr...

Materials and methods We have switched to Adalimumab treatment eight patients with chronic uveitis in whom, after 15–39 months of Infliximab infusions, recurrences of eye inflammations were increasing. Four were males, four females; in three cases uveitis was associated with JIA, in one with early-onset sarcoidosis, in one with Behçet disease, while three patients suffered from idiopathic uveit...