OBJECTIVE To determine the frequency of submandibular gland involvement in early oral cavity tumors. STUDY DESIGN Observational study. PLACE AND DURATION OF STUDY ENT Department, CMH, Rawalpindi, from January 2008 to December 2011. METHODOLOGY Data of 110 oral cavity tumors operated over 2008 - 2011 was retrieved from ENT OPD, tumor registry in AFIP and from Head and Neck Oncology Forum R...

Calorie restriction reduces mammary mitogenesis and tumorigenesis. To test whether epidermal growth factor (EGF) levels are influenced by calorie intake, 72 four-week-old C3H/HeOu mice were separated into two groups and either fed ad libitum (group AL) or calorie-restricted at a mean 19% (group CR). Three mice from each group were evaluated when 6, 8, 10, and 12 weeks old for submandibular glan...

INTRODUCTION Sialolithiasis is the most common cause of salivary gland disease and about 80% to 90% of stones occur in the submandibular gland (SMG). Among them, 40% of the SMG stones are located in the distal submandibular duct near the punctum, and they are removed through the intraoral approach. The other 60% of the SMG stones are located in the proximal submandibular duct or in the submandi...

BACKGROUND/AIM The submandibular gland is one of the three major salivary glands, producing a mixed secretion; this saliva is hypotonic compared to plasma. It also secretes glucose, but the mechanisms responsible for this process are poorly understood. Our study addressed the question whether glucose transporters are expressed and how are they localized within specific rodent submandibular cell...

Four poorly differentiated malignant lesions occurred in a 60-year-old Chinese male in the nasal cavity, submandibular gland, a lymph node in the neck, and the mandible. These malignant lesions developed within an 8-year period and each showed distinctive histological features. Among these malignant lesions, the neoplasm in the submandibular gland presented variegated histological and immunohis...

Ectopic thyroid gland is rarely seen in the submandibular region, thereby posing difficult diagnostic and management problems. Two Caucasian women presented with painful swelling in the submandibular region, which increased in size considerably during the preceding months. Ultrasound-guided fine needle biopsy (Ug-FNB) revealed ectopic thyroid tissue. In conclusion, ectopic thyroid gland with or...

Saliva is of major importance in taste, speech, swallowing, and protection against dental caries. Neck dissection surgery and/or radiotherapy may impair the function of the submandibular glands. Over the years, there has been a trend toward more conservative approaches to neck dissection. Metastasis to the submandibular gland itself is extremely rare and if removal of the lymph nodes of subleve...

Salivary gland cancers are uncommon malignancies of the head and neck region. Their site of origin can be major (parotid, submandibular and sublingual) or minor salivary gland (palate, nasal cavity, paranasal sinuses, trachea and lacrimal gland). Of all the salivary gland neoplasms, 85% are benign and 15% are malignant. Salivary gland malignancies comprise 3-6% of all head and neck cancers (Pin...

The differential diagnosis of a cystic lesion in the submandibular area can be difficult. We report a case of epidermal cyst of submandibular gland which is relatively rare compared to the commoner epidermoid cyst.

PURPOSE The aim of the present study was to evaluate the therapeutic efficiency of sialendoscopy-assisted operations in the treatment of submandibular gland stones. MATERIALS AND METHODS The data from 8 patients with sialolithiasis who underwent sialendoscopy from August 2015 to January 2016 at the Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University (...