Types Ia and Ib group B streptococcal (GBS) capsular polysaccharides (PSs) are structural isomers but are antigenically distinct. Immunization of healthy adults with GBS type Ia PS-tetanus toxoid (Ia-TT) or Ib-TT glycoconjugate vaccines induced > or = 4-fold increases in specific immunoglobulin G to the heterologous PS in more than two-thirds of subjects. Ib-TT vaccine-induced IgG bound with su...

OBJECTIVE The platelet glycoprotein Ib-IX (GP Ib-IX) receptor is a well-characterized adhesion receptor supporting hemostasis and thrombosis via interactions with von Willebrand factor. We examine the GP Ib-IX/von Willebrand factor axis in murine polymicrobial sepsis, as modeled by cecal ligation and puncture (CLP). APPROACH AND RESULTS Genetic absence of the GP Ib-IX ligand, von Willebrand f...

The availability of innumerable intelligent building (IB) products, and the current dearth of inclusive building component selection methods suggest that decision makers might be confronted with the quandary of forming a particular combination of components to suit the needs of a specific IB project. Despite this problem, few empirical studies have so far been undertaken to analyse the selectio...

The firm adhesion and transplatelet migration of leukocytes on vascular thrombus are dependent on the interaction of the leukocyte integrin Mac-1 ( M 2 , CD11b/CD18) and the platelet counter receptor glycoprotein (GP) Ib . Previous studies have established a central role for the I domain, a stretch of 200 amino acids within the M subunit, in the binding of GP Ib . This study was undertaken to e...

‎Let $tau$ be a subgroup functor and $H$ a $p$-subgroup of a finite group $G$‎. ‎Let $bar{G}=G/H_{G}$ and $bar{H}=H/H_{G}$‎. ‎We say that $H$ is $Phi$-$tau$-quasinormal in $G$ if for some $S$-quasinormal subgroup $bar{T}$ of $bar{G}$ and some $tau$-subgroup $bar{S}$ of $bar{G}$ contained in $bar{H}$‎, ‎$bar{H}bar{T}$ is $S$-quasinormal in $bar{G}$ and $bar{H}capbar{T}leq bar{S}Phi(bar{H})$‎. ‎I...

let $g$ be a finite group‎. ‎a subgroup‎ ‎$h$ of $g$ is called an $mathcal{h}$-subgroup in‎ ‎$g$ if $n_g(h)cap h^{g}leq h$ for all $gin‎ ‎g$. a subgroup $h$ of $g$ is called a weakly‎ ‎$mathcal{h}^{ast}$-subgroup in $g$ if there exists a‎ ‎subgroup $k$ of $g$ such that $g=hk$ and $hcap‎ ‎k$ is an $mathcal{h}$-subgroup in $g$. we‎ ‎investigate the structure of the finite group $g$ under the‎ ‎as...

Clostridium perfringens iota-toxin is a binary toxin consisting of two individual proteins, the binding component (Ib) and the enzyme component (Ia). Wild-type Ib bound to Vero cells at 4 and 37 degrees C and formed oligomers at 37 degrees C but not at 4 degrees C. The Ib-induced K(+) release from the cells was dependent on the oligomer formation of Ib in the cells, but the oligomer formation d...

CONTEXT Pseudohypoparathyroidism type 1b (PHP-Ib) is characterized by renal resistance to PTH (and, sometimes, a mild resistance to TSH) and absence of any features of Albright's hereditary osteodystrophy. Patients with PHP-Ib suffer of defects in the methylation pattern of the complex GNAS locus. PHP-Ib can be either sporadic or inherited in an autosomal dominant pattern. Whereas familial PHP-...

PURPOSE To investigate the expression and localization of the human gene encoding uroplakin Ib in ocular surface epithelium. METHODS The full-length cDNA of human uroplakin Ib was isolated from a cDNA library of human corneal epithelium, and the expression of uroplakin Ib in various tissues was examined by reverse transcription-polymerase chain reaction (RT-PCR). In cornea and conjunctiva, th...