BACKGROUND Subclinical left ventricular (LV) dysfunction has been inconsistently associated with early cognitive impairment, and mechanistic pathways have been poorly considered. We investigated the cross-sectional relationship between LV dysfunction and structural/functional measures of the brain and explored the role of potential mechanisms. METHOD AND RESULTS A total of 1338 individuals (6...

BACKGROUND Obesity predisposes to left ventricular (LV) dysfunction and heart failure; however, the risk of these complications has not been assessed in patients with a normal body mass index (BMI) but increased body fat content (normal-weight obesity, NWO). We hypothesized that LV performance in NWO may be impaired and sought to investigate potential contributors to cardiac functional abnormal...

BACKGROUND AND AIM Effects of atrial fibrillation (AF) and its ablative treatment on LV torsion have not yet been fully investigated. This study aimed to examine whether AF patterns of LV contraction and its ablative correction can exert a significant impact on LV torsion by velocity vector imaging (VVI). METHODS This case-control study conducted in Rajaie Cardiovascular, Medical and Research...

We aimed to investigate intradialytic changes in ventricular and atrial function using speckle tracking echocardiography (STE) pediatric hemodialysis (HD). Children with HD vintage > 3 months were enrolled, was performed prior to, during, after HD. STE analyzed GE EchoPAC. Left (LV) global longitudinal strain (GLS), rate (Sr), mechanical dispersion index (MDI) calculated as the average from api...

AIMS Patients with mild heart failure (HF) who are clinically compensated may have normal left ventricular (LV) stroke volume (SV). Despite this, altered intra-ventricular flow patterns have been recognized in these subjects. We hypothesized that, compared with normal LVs, flow in myopathic LVs would demonstrate a smaller proportion of inflow volume passing directly to ejection and diminished t...

CONTEXT Obesity and insulin resistance (IR) may produce disturbances of left ventricular (LV) function. Obese women with polycystic ovary syndrome (PCO), characterized by hormonal and metabolic abnormalities, are thought to be at particularly increased cardiovascular risk. OBJECTIVES We sought to determine the influence of IR on LV function in obese young women with and without PCO and withou...

BACKGROUND Evaluation of sensitive myocardial mechanics with speckle tracking echocardiography (STE) across the lifespan may reveal early indicators of cardiovascular disease (CVD) risk. Epicardial adipose tissue (EAT) and left ventricular (LV) myocardial dyssynchrony; subclinical risk-factors of CVD, are of particular clinical interest. However, the evolution of EAT and LV-dyssynchrony across ...

Elevated thyroid-stimulating hormone (TSH) levels often accompany impaired LV diastolic function and subtle systolic dysfunction in subclinical hypothyroidism (sHT). These cardiac dysfunctions are characterized by increases in mean aortic acceleration and pre-ejection/ejection time ratios. To explore the mechanism underlying these pathologies, we investigated the effects of TSH on sarcoplasmic ...

AIM To detect echocardiographic abnormalities in persons without cardiovascular risk factors and BP of 120/80 mm Hg or less. METHOD Detailed echocardiographic evaluation was done in 65 persons fulfilling above mentioned criteria. RESULTS Nearly 50% persons had cardiac remodeling and/or diastolic dysfunction. Pulmonary vein flow systolic velocity/diastolic velocity had significant negative c...