BACKGROUND Subclinical hypothyroidism has been associated with depressive symptoms in cross-sectional studies, but prospective data and data on subclinical hyperthyroidism are scarce. METHODS In the Leiden substudy of the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER), thyroid-stimulating hormone and free T4 levels were measured at baseline and repeated after 6 months in ad...

background: the purpose of the study was to examine whether patients with subclinical hypothyroidism (sch) should be excluded before making a diagnosis of polycystic ovary syndrome (pcos). methods: seven hundred sixteen patients, 462 with true pcos, 31 with pcos-sch, and 223 normal cycling women were enrolled. clinical, metabolic, and hormonal parameters among the groups were investigated. cont...

BACKGROUND Subclinical thyroid dysfunction might influence a bone health. We evaluated whether subclinical hypothyroidism adversely affects bone health including bone mineral density (BMD), level of vitamin D, and bone turnover status in patients with hip fracture. METHODS We evaluated 471 patients aged 50 years or older, who underwent hip fracture surgeries. BMD, level of vitamin D, bone tur...

PURPOSE To figure out plasma homocysteine (Hcy) status in patients with subclinical hypothyroidism (SH) and overt hypothyroidism (OH) compared with healthy subjects, and the effect of levothyroxine (L-T4) on plasma homocysteine status in patients with hypothyroidism. METHODS PubMed Web of Science, and The Cochrane Library were used to identify eligible studies. The Newcastle-Ottawa Quality As...

OBJECTIVE To identify risk factors for the development of statin-associated diabetes mellitus (DM). RESEARCH DESIGN AND METHODS The study was conducted in two phases. Phase one involved high-throughput in silico processing of a large amount of biomedical data to identify risk factors for the development of statin-associated DM. In phase two, the most prominent risk factor identified was confi...

BACKGROUND The purpose of this study was to determine the incidence of hypothyroidism after chemoradiation in head and neck squamous cell cancer (HNSCC). METHODS One hundred twenty-two patients treated with 3-dimensional conformal radiotherapy (3DCRT; 70 Gy/35#) or intensity-modulated radiation therapy (IMRT; 66 Gy/30#) in 2 identical simultaneous randomized trials were studied. Thyroid funct...