Repeated dose toxicity is of the utmost importance to characterize the toxicological profile of a chemical after repeated administration. Its evaluation refers to the Lowest-Observed-(Adverse)-Effect-Level (LO(A)EL) explicitly requested in several regulatory contexts, such as REACH and EC Regulation 1223/2009 on cosmetic products. So far in vivo tests have been the sole viable option to assess ...

The present study investigated safety/toxicity profile of fixed dose combination of Ofloxacin-Ornidazole injection in Mus musculus mice at three dose levels, ranging from asymptomatic to high dose. To enhance the antimicrobial spectrum of the quinolones against anaerobic organisms and gram positive bacteria, fixed dose combination of Ofloxacin and Ornidazole injection was introduced. It has bee...

The REACH Regulation requires information on acute oral toxicity for substances produced or imported in quantities greater than one ton per year. When registering, animal testing should be used as last resort. The standard acute oral toxicity test requires use of animals. Therefore, the European Chemicals Agency examined whether alternative ways exist to generate information on acute oral toxic...

60 adult Rattus novergicus (both sexes) of mean body weight of 150.0±3.5g were distributed into six groups of ten rats per group (same sex). The groups A, B, C, D, E and F were exposed to adjusted dosages of 0%, 20%, 40%, 60%, 80% and 100% of DDVP respectively by inhalation from day 1 to day 28. Biochemical analysis indicated that DDVP caused significant decrease (p<0.05) in GPT activity, WBC a...

Air quality indicators, i.e., PM10, NO2, O3, benzo[a]pyrene, and several organic tracer compounds were evaluated in an urban traffic station, a sub-urban background rural station of the air network Catalonia (Spain) from summer to winter 2019. The main sources that contribute aerosol PM toxicity determined. Traffic-related pollution dominated while biomass burning secondary (SOA) impact station...

abstract in respect to nano-technological studies and physiological and biochemical lesions of these materials on aquatic animals, in this study we examine the toxicity effects of nano-zinc oxide (zno nps) on hematological indices of common carp (cyprinus carpio). lc50 of nano zinc oxide was determined according to the mortality at 24, 48, 72 and 96 hours, respectively. during separate experime...