BACKGROUND Mutations of the UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine-kinase (GNE)-gene are causally related to GNE myopathy. Yet, underlying pathomechanisms of muscle fibre damage have remained elusive. In sporadic inclusion body myositis (sIBM), the pro-inflammatory cell-stress mediators αB-crystallin and inducible nitric oxide synthase (iNOS) are crucial markers of the disease ...

At a site near the end of the short arms of lampbrush bivalent 2 in the chicken (Gallus domesticus) there is always a marker structure that appears in the phase-contrast light microscope as a solid object with diffuse edges measuring about 4 microns across. When examined by transmission electron microscopy in thin section, this object appears as a loose bundle of fibres. In some preparations in...

In this paper a Constitutive equation to dcscribe the mechanical behaviour of materials, reinforced with unidirectional fibres, is presented. The material behaviour of both matrix and fibres may be viscoelastic. The constitutive equation is a linear relation between the second Piola-Kirchhoff stress tensor and the Green-Lagrange strain tensor. The effective relaxation functions in the constitut...

Recent years have seen an increasing public interest in issues related to energy saving and environmental pollution reduction in the building sector. As a result, many directives have been issued, the most important being the Directive 2010/31/EU (EPBD Recast) on the energy performance of buildings, which requires that “Member States shall ensure that by 31 December 2020 all new buildings are n...

NM (nemaline myopathy) is a rare genetic muscle disorder defined on the basis of muscle weakness and the presence of structural abnormalities in the muscle fibres, i.e. nemaline bodies. The related disorder cap myopathy is defined by cap-like structures located peripherally in the muscle fibres. Both disorders may be caused by mutations in the TPM2 gene encoding β-Tm (tropomyosin). Tm controls ...

Today, automobile and aircraft industry uses more and more robust and light-weight parts made of carbon fibres. To achieve high structural properties the carbon fibre mats are stitched in the preforming process using a sewing robot. The goal of this work is to develop an edge tracking system that continuously follows the seams. To work with the black and reflective carbon fibres a laser-scan se...

This paper presents an overview of the research performed to date by a Swedish interdisciplinary team of scientists striving to develop multifunctional composite materials for storage of electric energy in mechanical load paths. To realise structural batteries from polymer composites, research pursued on carbon fibres for use as negative electrode in the battery as well as on polymer electrolyt...