Lipid monolayers at an air-water interface can be compressed laterally and reach high surface density. Beyond a certain threshold, they become unstable and collapse. Lipid monolayer collapse plays an important role in the regulation of surface tension at the air-liquid interface in the lungs. Although the structures of lipid aggregates formed upon collapse can be characterized experimentally, t...

it is difficult to develop an algorithm which is able to generate the appropriate mesh around the interfaces in bimaterials. in this study, a corresponding algorithm is proposed for this class of unified structures made from different materials with arbitrary shapes. the non-uniform mesh is generated adaptively based on advancing front technique available in abaqus software. implementing severa...

6- Mercaptopurine (6-MP) is widely used in clinic as an immunosuppressive for treatment of acute lymphocytic leukemia, Crohn's disease, and ulcerative colitis with documented unpredictable hepatotoxicity. The potential molecular cytotoxic mechanisms of 6-MP against isolated rat hepatocytes were searched in this study using “Accelerated Cytotoxicity Mechanism Screening (ACMS)” techniques. The co...

docetaxel (dtx) is one of the most widely used drugs in oncology due to its high efficacy against several cancers. though, its routine clinical administration, formulated in tween 80, causes serious side effects. polylactide-co-glycolide (plga), biodegradable polyester synthesized and approved for human use, is employed to overcome this problem. in this investigation, we compare the cytotoxic m...

Coal and gas outbursts are a potentially fatal hazard that must be managed when mining gassy coal seams. Mining-induced stress plays an important role in outbursts, while elastic potential is accumulated to provide energy for outburst. In this study, large-scale true triaxial (LSTT) apparatus was developed conduct experiments understand the outburst mechanism mining-induced geo-stress evolution...

We study the regulating mechanism of p53 on the properties of cell cycle dynamics in the light of the proposed model of interacting p53 and cell cycle networks via p53. Irradiation (IR) introduce to p53 compel p53 dynamics to suffer different phases, namely oscillating and oscillation death (stabilized) phases. The IR induced p53 dynamics undergo collapse of oscillation with collapse time Δt wh...

silicon is known to ameliorate the deleterious effects of drought on plant growth. we evaluated growth of wheat (triticum aestivum l. cv. chamran) under water-deficit stress induced by polyethylene glycol as affected by si application. in this article, the effects of si (as potassium silicate) on some parameters related to growth, chlorophyll concentration relative water content (rwc), electrol...

The adrenocortical response to major surgery was assessed by the measurement of plasma corticosteroid concentrations in patients receiving either a general anaesthetic alone or in combination with an epidural block. The expected increase in plasma corticosteroid concentration seen in the general anaesthesia group was significantly inhibited by epidural block. The inhibition was related to the d...