− The aim of this study was to evaluate the anti-diabetic effects of the water extract of Lespedeza cuneata (LCW) using rat insulinoma (RIN) m5F cells and streptozotocin (STZ)-induced diabetic rats. The effect of LCW on the protection of pancreatic beta cells was assessed using MTT assay, and nitric oxide production was assessed using Griess reagent. STZ-induced diabetic rats were treated with ...

Experiments were performed to evaluate the hypothesis that the early stage of Type 1 diabetes mellitus (DM) increases renal angiotensin II (AngII) concentration and angiotensin type 1 (AT) receptor protein levels. Nineteen or twenty days after vehicle (Sham rats) or streptozotocin (STZ rats) treatment, plasma [AngII] was higher in STZ rats (152 +/- 23 fmol/ml) than in Sham rats (101 +/- 7 fmol/...

The present study was conducted to examine the effect of administration of conophylline (CnP) and betacellulinδ4 (BTCδ4) on the β-cell mass in neonatal streptozotocin-treated rats (neonatal sTz rats). sTz (100 μg/g) was injected into neonatal rats, and then CnP (2 μg/g) and/or BTCδ4 (200 pmol/g) were administered to neonatal sTz rats for 1 week. The plasma glucose concentration was monitored, a...

Streptozotocin (STZ) is a diabetogenic agent extensively used to induce diabetes and to study complications including diabetic peripheral neuropathy (DPN). While studying the influence of transient receptor potential vanilloid 1 (TRPV1) on DPN in the STZ-induced diabetic mouse model, we found that a proportion of STZ-treated mice was nondiabetic but still exhibited hyperalgesia. To understand t...

We compared the effects of streptozotocin (STZ) treatment on serum cholesterol and lipoprotein levels in spontaneously hyperlipidemic rats (HLR), a hereditary hyperlipidemic model animal, with those in Sprague-Dawley rats (SDR). The body weight of control SDR and HLR were increased continuously for 30 days. Both SDR and HLR lost their body weight after STZ administration. Glucose levels of SDR ...

Diabetes mellitus complicates pregnancies, leading to diseases in adult life in the offspring. Asymmetric dimethylarginine (ADMA) is increased in diabetes mellitus, kidney disease, and hypertension. We tested whether maternal diabetes causes increased ADMA in rats, resulting in kidney disease and hypertension in the adult offspring, and whether these can be prevented by maternal citrulline supp...

Diabetes mellitus (DM) is a major cause of morbidity and mortality worldwide, and its complications are prominent public health issues. Many experimental models of streptozotocin (STZ)-induced and high-fat diet (HF)-induced DM have been used to study this disease. Studies have indicated that unilateral nephrectomy (UN) accelerates the development of diabetic nephropathy. We hypothesized that UN...

Abstract Background The current study aimed to investigate the oxidative stress in rat liver with diabetes mellitus (DM) as well protective effects of N-acetylcysteine (NAC) on irisin expression. Methods Twenty-eight male Wistar rats were divided into four groups, 7 each group, and 30-day regimens experimental or control groups. NAC-treated group is follows: 100 mg/kg once daily was administere...

BACKGROUND Diabetes in humans induces chronic complications such as cardiovascular damage, cataracts and retinopathy, nephropathy and polyneuropathy. The most common animal model of human diabetes is streptozotocin (STZ)-induced diabetes in the rat. The present study investigated the effects of Nigella sativa hydroalcholic extract on glucose concentrations in streptozotocin (STZ) diabetic rats....

Guizotia abyssinica Cass. widely grown plant of southern India, seed oil which are said to be healthy source oil. Diabetes mellitus is a metabolic disorder affecting major population worldwide. Nutritive oils and fats essential in current scenario. Hence antidiabetic property Cass tested Streptozotocin induced diabetes Wistar albino Rats. Materials methods: Test drug collected, authenticated, p...