Abamectin is a bio-insecticide, derived from the soil bacteria Streptomyces avermitilis. This insecticide used in public health and agriculture to protect crops. Major adverse impacts of are neurological symptoms acting on peripheral nervous system. The aim current study reveal toxic effects chick embryo Ross 308 including morphological histological changes acetyl cholinesterase activity. 120 f...

Bioconversion using microorganisms and their enzymes is an important tool in many industrial fields. The discovery of useful new microbial contributes to the development industries utilizing bioprocesses. Streptomyces sp. EAS-AB2608, isolated from a soil sample collected Japan, can convert tetrahydrobenzotriazole CPD-1 (a selective positive allosteric modulator metabotropic glutamate receptor 5...

Most microbial secondary metabolites are producec as complexes of closely related compoundsby theii producing organisms. The avermectins1*, milbemycins2 and nemadectins3~5) are typical examples produced ii such a manner. The milbemyciif complex is known t( consist of more than twenty components6 ~ 8), however only a few are commercial products. A rationale for thii phenomenon may be related to ...

The level of activity of avermectin B O-methyltransferase, the enzyme which catalyzes the conversion of avermectin B components to avermectin A components, was analyzed in a series of "Streptomyces avermitilis" mutants selected for increased production of the avermectins. In all of the mutants, increased avermectin production was accompanied by increased avermectin B O-methyltransferase activit...