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Wnt target gene activation in C. elegans requires simultaneous elevation of β-catenin/SYS-1 and reduction of TCF/POP-1 nuclear levels within the same signal-responsive cell. SYS-1 binds to the conserved N-terminal β-catenin-binding domain (CBD) of POP-1 and functions as a transcriptional co-activator. Phosphorylation of POP-1 by LIT-1, the C. elegans Nemo-like kinase homolog, promotes POP-1 nuc...

Current genome walking methods are cumbersome to perform and can result in non-specific products. Here, we demonstrate the use of partially overlapping primer-based PCR (POP-PCR), a direct genome walking technique for the isolation of unknown flanking regions. This method exploits the partially overlapping characteristic at the 3' ends of a set of POP primers (walking primers), which guarantees...

Currently, mutations in three genes, namely rrs, rpsL, and gidB, encoding 16S rRNA, ribosomal protein S12, and 16S rRNA-specific methyltransferase, respectively, are considered to be involved in conferring resistance to streptomycin (STR) in Mycobacterium tuberculosis. The aim of this study was to investigate the spectrum and frequency of these mutations in M. tuberculosis clinical isolates, bo...

Previous research has shown that repetition of a task-relevant attention-capturing feature facilitates pop-out search. This priming of pop-out effect is due to some residual memory from recent trials. We explore two possible mechanisms of priming of pop-out: a top-down attentional benefit from a memory of the previous target representation that is stored in visual short-term memory (VSTM) and a...

Visual pop-out occurs when a unique visual target (e.g., a feature singleton) is present in a set of homogeneous distractors. However, the role of visual awareness in this process remains unclear. In the experiments reported here, we showed that even though subjects were not aware of a suppressed pop-out display, their subsequent performance on an orientationdiscrimination task was significantl...

Sequences of generalized Lagrangian duals and their SOS (sums of squares of polynomials) relaxations for a POP (polynomial optimization problem) are introduced. Sparsity of polynomials in the POP is used to reduce the sizes of the Lagrangian duals and their SOS relaxations. It is proved that the optimal values of the Lagrangian duals in the sequence converge to the optimal value of the POP usin...

background: bleaching the discoloured teeth may affect the tooth/composite interface. the aim of this in vitro experimental study was to evaluate the effect of vital tooth bleaching on microleakage of existent class v composite resin restorations bonded with three dental bonding agents.     methods: class v cavities were prepared on buccal surfaces of 72 intact, extracted human anterior teeth w...

Analysis of the effects of cyclosporine A (25-28 mgkg(-1)) and/or methotrexate (0.1 mgkg(-1)) treatments on dipeptidyl peptidase IV (DPPIV) and prolyl oligopeptidase (POP) activities and on algesic response in two distinct status of murine macrophages (Mphis) was undertaken. In resident Mphis, DPPIV and POP were affected by neither individual nor combined treatments. In thioglycolate-elicited M...

background: prompt l-pop is a self-etching dentin adhesive, which is recommended to use with both compomers and composite resins. the aims of this investigation were to determine and compare the microleakage, shear bond strength, and shear push out strength of composite and compomer to dentin with application of prompt l-pop as adhesive system. methods: after application of prompt l-pop on the ...