we have first to look at its effects in small doses and then in larger and constant doses. I will not enter into arguments about the harm, misery and crime it is responsible for, suffice it to say that it can save as well as destroy. Alcohol in moderate doses stimulates the brains, the respiratory and cardiac nerves, and produces capillary dilatation, diaphoresis, and a sensation of warmth, but...

In the Proceedings of the Royal Society (Series B., Vol. 76, p. I38) Professor Moore published a series of observations which he, together with Messrs. Alexander, Kelly and Roaf, had made on the gastric contents of patients who were suffering from carcinoma situated in various parts of the body. As the result of these observations they came to the conclusion that the well known absence of free ...

A review of the literature reveals comparatively little information concerning gastric acidity in normal individuals. The available data are based mostly on test meals of the Ewald type. In addition to the technical difficulties in analysis inherent in these methods, they fail to give a maximum stimulation for secretion of gastric juice, as do histamine or histamine plus alcohol. Consequently t...

1. Gastric juice, saliva and ovarian-cyst fluid were fractionated into glycoprotein components by centrifuging to equilibrium in a caesium chloride density gradient. 2. The glycoprotein fractions from the gastric juice of two group O non-secretors, two group O secretors and three group A secretors all formed insoluble complexes with concanavalin A. 3. Fractions showing maximum interaction with ...

The pharmacokinetics of acetaminophen was investigated following oral dosing to Shiba goats in order to evaluate the properties of gastric emptying. Acetaminophen was intravenously and orally administered at 30 mg/kg body weight to goats using a crossover design with a 3-week washout period. The stability of acetaminophen in rumen juice was also assessed. Acetaminophen concentrations were measu...

Intrinsic factor antibody may sometimes be concealed in the gastric secretions of pernicious anaemia subjects, being complexed with residual amounts of intrinsic factor.A method is described for dissociating intrinsic factor from its antibody. Antibody to the vitamin-B(12)-binding site of intrinsic factor was identified in 16 (57%) out of 28 samples of pernicious anaemia gastric juice after dis...

are not particularly noted for the pleasure which they give to their recipients. One meaning of the word dummy is a "counterfeit object." This seems to me the right word to describe a form of treatment which is intended to have no effect and I follow those who use it. A placebo is something which is intended to act through a psychological mechanism. It is an aid to therapeutic suggestion, but t...

The spontaneous output of pepsin was not found to be significantly reduced in this study of patients who had had a vagotomy.

1. Omeprazole (R,S)-5-methoxy-2-[[(4-methoxy-3,5-dime-thylpyridine-2-yl)methyl]sulphinyl]-1Hbenzimidazole (CAS Number 73590-58-6) is a substituted benzimidazole which inhibits gastric secretion in animals and humans. It is intended for use for treatment of gastric ulcers in horses as an oral paste containing 37% w/w omeprazole at the dose of 4 mg omeprazole/kg bw/day for 28 days, followed by an...

The obese patient presenting for surgery is at high risk for developing the pulmonary acid aspiration syndrome due to a large volume of acidic gastric contents. Cimetidine, an H 2 receptor antagonist, reduces gastric secretion and increases gastric pH. In the following study, cimetidine increased gastric pH in the obese patient, but had no effect on gastric volume. By increasing gastric pH, cim...