The identification of a fraction of cancer stem cells (CSCs) associated with resistance to chemotherapy in most solid tumors leads to the dogma that eliminating this fraction will cure cancer. Experimental data has challenged this simplistic and optimistic model. Opposite to the classical cancer stem cell model, we introduced the stemness phenotype model (SPM), which proposed that all glioma ce...

Reprogramming committed differentiated cells into stable stem cells has been achieved in various settings in vitro. A new study by Tata et al. (2013) demonstrates that, when airway basal stem cells are in demand, spontaneous reprogramming occurs in vivo as committed secretory cells convert into stem cells to replenish the stem cell pool. The authors use lineage-tracing strategies to show that, ...

CD133 has been implicated as a cancer stem cell (CSC) surface marker in several malignancies including pancreatic cancer. However, the functional role of this surface glycoprotein in the cancer stem cell remains elusive. In this study, we determined that CD133 overexpression induced "stemness" properties in MIA-PaCa2 cells along with increased tumorigenicity, tumor progression, and metastasis i...

Received: July 25, 2016; Accepted: August 08, 2016; Published: August 08, 2016 The pluripotency of embryonic stem cells, which are capable of unlimited self-renewal and differentiation into every type of cell in the body, is provided by the extensive expression of genes encoding stemness factors, among which the transcription factors such as Sox2, Pou5f1, Nanog are most frequently enumerated [1...

Glioblastoma multiforme (GBM) is a rapidly progressive brain tumor with a median survival of 15-19 months. Therapeutic resistance and recurrence of the disease is attributed to cancer stem cells (CSC). Here, we report that CMV70-3P miRNA encoded by CMV increases GBM CSC stemness. Inhibition of CMV70-3P expression using oligo inhibitors significantly attenuated the ability of primary glioma cell...

During asymmetric mitosis, both in male Drosophila germline stem cells and in mouse embryo neural progenitors, the mother centrosome is retained by the self-renewed cell; hence suggesting that mother centrosome inheritance might contribute to stemness. We test this hypothesis in Drosophila neuroblasts (NBs) tracing photo converted centrioles and a daughter-centriole-specific marker generated by...

G-protein coupled estrogen receptor (GPER) is a transmembrane that mediates non-genomic effects of estrogen. This study aimed to investigate the role GPER in stemness formation and malignancies triple negative breast cancer (TNBC) cells. Spheroids MDA-MB-468 cells were induced by mammosphere culture, proportion CD44+ /CD24−/low stem cell subpopulation was detected. Malignant characteristics, ex...

Background and Aims: Previous studies have shown that adipose-derived mesenchymal stem/ stromal cells are one of the sources of mesenchymal stem cells (MSCs) with the capacity to differentiate into various mesodermal cell lineages. MSCs with cytokines secretion capability, which contributes to repair damaged tissues have gained wide credence for future cell-based therapeutic applications. In th...

hyperspectral sensors provide a large number of spectral bands. this massive and complex data structure of hyperspectral images presents a challenge to traditional data processing techniques. therefore, reducing the dimensionality of hyperspectral images without losing important information is a very important issue for the remote sensing community. we propose to use overlap-based feature weigh...