The effect of variations in pitch, loudness, and timbre on the perception of the dynamics of isolated instrumental tones is investigated. A full factorial design was used in a listening experiment. The subjects were asked to indicate the perceived dynamics of each stimulus on a scale from pianissimo to fortissimo. Statistical analysis showed that for the instruments included (i.e., clarinet, fl...

BACKGROUND We aimed at assessing the benefit-to-risk ratio of activated protein C (drotrecogin-alfa activated, DAA) and corticosteroids, given alone or in combination, in patients with septic shock. METHODS We implemented an investigator-led, publicly funded, multicenter, randomized according to a 2 × 2 factorial design, placebo-controlled, double-blind trial in four parallel groups in which ...

4-Androstenedione (AD), a 19-carbon steroid hormone is an oxidation product of phytosterol fermentation by Mycobacterium sp. The isolation of the product from the fermentation broth is a challenging task. Downstream processing is an important aspect of all biotechnological processes and has significant implications on quality and yield of the final product. In the present study, the statistical...

The target of the present study is to use experimental design in screening and optimizing experimental variables to develop a spectrophotometric method for determination of Cefdinir (CFN) antibiotic. The proposed method is based on the oxidative coupling reaction of CFN with 3methylbenzothiazolinone-2hydrazone (MBTH) in presence of FeCl3 in acidic medium forming a green colored chromogen measur...

This paper focuses on Optimal Experimental Design to train a Projection Pursuit Regression (PPR) model used for fault detection. A novel experimental design method, referred to as Gaussian Probability Design, is proposed and compared with the conventional Factorial Design. The Gaussian Probability Design automatically searches for the sparseness of the data, and adds pairs of training data on b...

Justification of production and manufacturing processes overtime, process capability in the concept of statistical control has been of great importance because it has promoted the production of products that satisfy the expectation of consumers. This paper aimed at promoting the adoption of quality process capability design in a bid to improve the process stability of a process and improve the ...

Two factors having the same set of levels are said to be homologous. This paper aims to extend the domain of factorial models to designs that include homologous factors. In doing so, it is necessary rst to identify the characteristic property of those vector spaces that constitute the standard factorial models. We argue here that essentially every interesting statistical model speciied by a vec...

Marketers have recently begun to embrace complex experimental designs for marketing and advertising testing. Full-factorial, fractional-factorial and Plackett–Burman designs have given marketers new statistical tools to increase the speed, power, and profitability of their testing programs. This case study shows how well constructed and managed experimental designs offer marketing professionals...

Different types of factorial experimental designs can be used in compatibility studies of drug development, where many different factors and their interactions should be evaluated to predict their effects on the degradation of the drug substance under study. All possible main and interaction effects of different potential excipients that can constitute the drug product should be evaluated in or...