The Drk SH3-SH2-SH3 adaptor protein has been genetically identified in a screen for rate-limiting components acting downstream of the Sevenless (Sev) receptor tyrosine kinase in the developing eye of Drosophila. It provides a link between the activated Sev receptor and Sos, a guanine nucleotide release factor that activates Ras1. We have used a combined biochemical and genetic approach to study...

Doubly resolvable 2-(v,k,λ) designs (DRDs) with small parameters and their resolutions which have orthogonal resolutions (RORs) are constructed and classified up to isomorphism. Exact values or lower bounds on the number of the nonisomorphic sets of m mutually orthogonal resolutions (m-MORs) are presented. The implemented algorithms and the parameter range of this method are discussed, and the ...

Mesenchymal stem cell (MSC)-based therapies for articular cartilage regeneration are effective mostly due to paracrine signals mediated by extracellular vesicles, especially small vesicles (sEV). However, it is unknown whether dental follicle cell-derived sEV (DFC-sEV) affect in temporomandibular joint osteoarthritis (TMJ-OA). In this study, the effects of DFC-sEV on IL-1β-induced mandibular co...

In this paper we introduce the class of Wp scale mixture random vectors with a particular radial decomposition and a independent splitting property specified by some random variable Wp, p ∈ (0,∞). We derive several conditional limit results assuming that the distribution of the random radius is in the max-domain of attraction of a univariate extreme value distribution andWp has a certain tail a...

Activation of the Sevenless (Sev) receptor tyrosine kinase (RTK) in the developing Drosophila eye is required for the specification of the R7 photoreceptor cell fate. Daughter of Sevenless (Dos), a putative multi-site adaptor protein, is a substrate of the Sev kinase and is known to associate with the tyrosine phosphatase Corkscrew (Csw). Binding of Csw to Dos depends on the Csw Src homology 2 ...

In this paper we introduce the class of Lp scale mixture random vectors which includes beta-independent random vectors and Lp Dirichlet ones. We derive several conditional limit results assuming that the associated random radius of the Lp scale mixture random vectors have distribution function in the max-domain of attraction of a univariate extreme value distribution function. As an application...

Suppose, as an idealization, that sensory intensity is coded in peripheral channels as identical Poisson pulse trains with intensity parameter a power function of signal intensity. Discrimination models based on either an average count computed over a fixed time or an average time computed for a fixed count per channel have difEculty in fitting the Weber function (AI/I versus I) if the free par...

Preconditioning with sevoflurane (SEV) can protect against ischemia-reperfusion injury in several organs, however, the benefits of SEV against acute lung injury (ALI), induced by intestinal ischemia-reperfusion (IIR), and the underlying mechanisms remain to be elucidated. The present study was designed to investigate the effects of SEV preconditioning on IIR-mediated ALI and the associated mech...

We describe the development of novel lentivirus vectors based on simian immunodeficiency virus from African green monkey (SIVagm) pseudotyped with Sendai virus (SeV) envelope glycoproteins. SeV fusion (F) and hemagglutinin-neuraminidase (HN) proteins were successfully incorporated into the SIVagm-based vector by truncation of the cytoplasmic tail of the F protein and by addition of the cytoplas...