A neuploidy is a hallmark of cancer, but the path from mutation to extra chromosomes is unclear. Now, Caldwell et al. help fi ll this gap, showing that a cancer-causing mutation promotes chromosome doubling by unfastening the mitotic spindle and hindering cell division. The genome of a cancer cell is a mess, with breaks, rearrangements, and super-fl uous chromosomes. Many researchers speculate ...

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  Sarcoidosis is a systemic disease that is characterized with noncaseating granulomatous nodules which present in multiple organs specially lungs (90%) . Incidence of masses due to Sarcoidosis in upper extremity is low and most cases present in association with involvement of pulmonary hilary lymph nodes. In this article we present a rare case of Sarcoidosis which presented as a single soft ti...