Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and has a poor prognosis. Epigenetic modification been shown to be deregulated during HCC development by dramatically impacting differentiation, proliferation function of cells. One important epigenetic DNA methylation which methyl groups are added cytosines without changing sequence itself. Studies found that methylated...

introduction worldwide, chronic liver disease is a major cause of morbidity and mortality. causes of elevated serum alanine aminotransferase (alt) levels vary depending on the population under study. the aim of this study is to evaluate the frequency and causes of persistently elevated alt levels in patients of the gastroenterology (gi) clinics in ghaem and emam reza hospitals in mashhad, iran....

UNLABELLED Several authors reported the superiority of (68)Ga-DOTANOC PET/CT to conventional imaging (CI) for the assessment of neuroendocrine tumors (NET). However, the detection of a higher number of lesions is not necessarily followed by a modification of disease stage or therapeutic approach. The aim of this study was to assess the impact of (68)Ga-DOTANOC PET/CT on the clinical management ...

the liver is a multifactorial organ which is involved in a number of critical excretory, synthetic and metabolic functions. although the term 'liver function test' is commonly used, it is imprecise since many of the tests, such as transaminase, do not measure liver function. therefore, these tests should be referred to as 'liver enzyme tests', and 'liver function tests' should be the term used ...