Metabolic reprogramming in stromal cells plays an essential role in regulating tumour growth. The metabolic activities of tumour-associated macrophages (TAMs) in colorectal cancer (CRC) are incompletely characterized. Here, we identify TAM-derived factors and their roles in the development of CRC. We demonstrate that ABHD5, a lipolytic co-activator, is ectopically expressed in CRC-associated ma...

Mammalian social organizations require the ability to recognize and remember individual conspecifics. This social recognition memory (SRM) can be examined in rodents using their innate tendency to investigate novel conspecifics more persistently than familiar ones. Here we used the SRM paradigm to examine the influence of housing conditions on the social memory of adult rats. We found that acut...

Microspatial arrangements of sulfate-reducing microorganisms (SRM) in surface microbial mats (~1.5 mm) forming open marine stromatolites were investigated. Previous research revealed three different mat types associated with these stromatolites, each with a unique petrographic signature. Here we focused on comparing "non-lithifying" (Type-1) and "lithifying" (Type-2) mats. Our results revealed ...

The purpose of this study was to expand and validate the cartilage damage index (CDI) to detect cartilage damage in the lateral tibiofemoral compartment. We used an iterative 3-step process to develop and validate the lateral CDI: development (100 knees), testing (80 knees), and validation (100 knees). The validation set included 100 knees from the Osteoarthritis Initiative that was enriched to...

This paper presents a simple and novel procedure for acoustic noise reduction in Switched Reluctance Motors (SRMs) drive. The main sources of acoustic noise in a SRM are the radial magnetic force and torque ripple. To investigate the radial force, an analytical relationship between motor designs and drive parameters is required. Thus, in this method two mathematical methods for calculation of r...

In targeted proteomics using liquid chromatography-tandem triple quadrupole mass spectrometry (LC/MS/MS) in the selected reaction monitoring (SRM) mode, selecting the best observable or visible peptides is a key step in the development of SRM assay methods of target proteins. A direct comparison of signal intensities among all candidate peptides by brute-force LC/MS/MS analysis is a concrete ap...

This paper describes work on early detection of space launch vehicle failures that could lead to loss of control during ascent. The particular focus is on the Solid Rocket Motor (SRM) comprising First Stage of the Crew Launch Vehicle (CLV). Some of the most important failure modes leading to loss of vehicle control are caused by hot gases ejected from the SRM combustion chamber through a case b...

Spatial separation of a target (T) stimulus from a masker (M) often improves detectability of the target, a phenomenon known as the spatial release from masking (SRM). When the masker is a noise, two main factors contribute to SRM: changes in the target-to-masker ratio dominate the performance at high frequencies, while binaural processing dominates at low frequencies. Previous neurophysiologic...

We discuss empirical comparison of analytical methods for model selection. Currently, there is no consensus on the ‘best’ method for finite-sample estimation problems, even for the simple case of linear estimators. This paper presents empirical comparisons between classical statistical methods (AIC, BIC) and the SRM method (based on VC-theory) for regression problems. Our study is motivated by ...

The business is encountering a problem that the profit is gradually lesser. Therefore, the enterprise will devote to develop the technique for enhancing their competitive capability. Recently, supplier relationship management (SRM) which the way to manage the relationship between supplier and business is a new concept proposed to address such issue. In this study, we will transform the CSLC mod...