The signal recognition particle receptor (SR) is required for the cotranslational targeting of both secretory and membrane proteins to the endoplasmic reticulum (ER) membrane. During targeting, the SR interacts with the signal recognition particle (SRP) which is bound to the signal sequence of the nascent protein chain. This interaction catalyzes the GTP-dependent transfer of the nascent chain ...

Strontium (Sr) can promote the process of bone formation. To improve bioactivity, porous allograft bone scaffolds (ABS) were doped with Sr and the mechanical strength and bioactivity of the scaffolds were evaluated. Sr-doped ABS were prepared using the ion exchange method. The density and distribution of Sr in bone scaffolds were investigated by inductively coupled plasma optical emission spect...

several investigations have been devoted towards understanding the coating process in fluidized beds. most of these studies focused on spraying liquid droplets over the bed. however, due to the complexity of these systems, more investigations are still required to quantify the effect of operating conditions on the coating criteria. the present work aims at fundamentally understanding and precis...

OBJECTIVES Identify pediatrician (faculty and resident) beliefs about spirituality and religion (SR) in medicine and the relationship of those beliefs to SR behavior and experiences in clinical practice. METHODS A self-report questionnaire was administered to full-time pediatric faculty (N = 65) and residents (N = 56) of an urban children's hospital affiliated with a school of medicine. The r...

AIM To investigate the effect of a single amino acid mutation in human class B scavenger receptor I (SR-BI) on the infectivity of cell culture-derived hepatitis C virus (HCVcc) in SR-BI knock-down Huh7-siSR-BI cells. METHODS Site-directed mutagenesis was used to construct the SR-BI S112F mutation, and the mutation was confirmed by nucleotide sequencing. SR-BI knock-down Huh7-siSR-BI cells wer...

RATIONALE Sarcoplasmic reticulum (SR) Ca(2+) cycling is key to normal excitation-contraction coupling but may also contribute to pathological cardiac alternans and arrhythmia. OBJECTIVE To measure intra-SR free [Ca(2+)] ([Ca(2+)]SR) changes in intact hearts during alternans and ventricular fibrillation (VF). METHODS AND RESULTS Simultaneous optical mapping of Vm (with RH237) and [Ca(2+)]SR ...

Researchers have been focused on the influences of flowing fluid on the corrosion of bare metals, but there is little emphasis on the degradation of metal-protective coating. Evaluating the metal-protective coating usually uses the Electrochemical Impedance Spectroscopy (EIS) method. EIS is a technique used for evaluating coating permeability or barrier performance based on the electrical imped...

Novel scaffolds composed of poly(L-lactic acid) (PLLA) skeleton covered with bonelike apatite or apatite/collagen composite were produced via a combined phase-separation technique and an accelerated biomimetic coating process. Saos-2 osteoblast-like cells were used to evaluate the cellular behaviors on these biomimetic coatings. Cell morphologies on the surfaces of PLLA scaffolds, PLLA scaffold...

in this research, b4c-ni cermet coating was sprayed on the surface of 4130 steel from b4c and ni feed-stockpowders using high velocity oxy-fuel (hvof) method. in order to characterize the tribological behavior of thecoating, ball on disk wear tests were done at the ambient temperature and under the loads of 1, 3 and 5 n.phase analysis of the coating after spraying was studied by x-ray diffracto...